Lopressor

Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 11/18/2021
Lopressor Side Effects Center

What Is Lopressor?

Lopressor (metoprolol tartrate) Tablets and Injection is a selective beta-adrenoreceptor blocking agent (beta-blocker) used to treat high blood presure (hypertension), angina, and heart attacks. Lopressor is available as a generic.

What Are Side Effects of Lopressor?

Common side effects of Lopressor include

Serious side effects of Lopressor include

Dosage for Lopressor

Lopressor USP is available as 50 and 100 mg strength tablets for oral administration and as (metoprolol tartrate) Injection, USP in 5 mg strength, in 5 ml ampoules for IV administration. Usual oral dosage is 100 mg per day in single or divided doses; IV begins with a 5 mg injection. Patients with bronchospastic disease should not take Lopressor.

What Drugs, Substances, or Supplements Interact with Lopressor?

Lopressor may interact with cimetidine, clonidine, digoxin, ritonavir, terbinafine, diuretics (water pills), cold medicines, stimulant medicines, diet pills, anti-malaria medications, medicines to treat depression or mental illness, MAO inhibitors, diabetes medications, heart medications, or medicines for asthma or other breathing disorders. Tell your doctor all medications and supplements you use.

Lopressor During Pregnancy or Breastfeeding

There are no adequate and well-controlled studies of Lopressor in pregnant women, and caution should be exercised when Lopressor is administered to a woman breastfeeding an infant as small amounts of Lopressor are excreted in breast milk. Safety and effectiveness of Lopressor in pediatric patients have not been established.

Additional Information

Our Lopressor Tablets, USP and Injection, USP Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Lopressor Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • very slow heartbeats;
  • a light-headed feeling, like you might pass out;
  • shortness of breath (even with mild exertion), swelling, rapid weight gain; or
  • cold feeling in your hands and feet.

Common side effects may include:

  • dizziness, tired feeling;
  • depression, confusion, memory problems;
  • nightmares, trouble sleeping;
  • diarrhea; or
  • mild itching or rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Lopressor (Metoprolol Tartrate)

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Lopressor Professional Information

SIDE EFFECTS

Hypertension And Angina

These adverse reactions were reported for treatment with oral Lopressor. Most adverse effects have been mild and transient.

Central Nervous System

Tiredness and dizziness have occurred in about 10 of 100 patients. Depression has been reported in about 5 of 100 patients. Mental confusion and short-term memory loss have been reported. Headache, nightmares, and insomnia have also been reported.

Cardiovascular

Shortness of breath and bradycardia have occurred in approximately 3 of 100 patients. Cold extremities; arterial insufficiency, usually of the Raynaud type; palpitations; congestive heart failure; peripheral edema; and hypotension have been reported in about 1 of 100 patients. Gangrene in patients with pre-existing severe peripheral circulatory disorders has also been reported very rarely. (See CONTRAINDICATIONS, WARNINGS, and PRECAUTIONS.)

Respiratory

Wheezing (bronchospasm) and dyspnea have been reported in about 1 of 100 patients (see WARNINGS). Rhinitis has also been reported.

Gastrointestinal

Diarrhea has occurred in about 5 of 100 patients. Nausea, dry mouth, gastric pain, constipation, flatulence, and heartburn have been reported in about 1 of 100 patients. Vomiting was a common occurrence. Postmarketing experience reveals very rare reports of hepatitis, jaundice and nonspecific hepatic dysfunction. Isolated cases of transaminase, alkaline phosphatase, and lactic dehydrogenase elevations have also been reported.

Hypersensitive Reactions

Pruritus or rash have occurred in about 5 of 100 patients. Very rarely, photosensitivity and worsening of psoriasis has been reported.

Miscellaneous

Peyronie's disease has been reported in fewer than 1 of 100,000 patients. Musculoskeletal pain, blurred vision, and tinnitus have also been reported.

There have been rare reports of reversible alopecia, agranulocytosis, and dry eyes. Discontinuation of the drug should be considered if any such reaction is not otherwise explicable. There have been very rare reports of weight gain, arthritis, and retroperitoneal fibrosis (relationship to Lopressor has not been definitely established).

The oculomucocutaneous syndrome associated with the beta blocker practolol has not been reported with Lopressor.

Myocardial Infarction

These adverse reactions were reported from treatment regimens where intravenous Lopressor was administered, when tolerated.

Central Nervous System: Tiredness has been reported in about 1 of 100 patients. Vertigo, sleep disturbances, hallucinations, headache, dizziness, visual disturbances, confusion, and reduced libido have also been reported, but a drug relationship is not clear.

Cardiovascular: In the randomized comparison of Lopressor and placebo described in the CLINICAL PHARMACOLOGY section, the following adverse reactions were reported:

  Lopressor® Placebo
Hypotension (systolic BP < 90 mmHg) 27.4% 23.2%
Bradycardia (heart rate < 40 beats/min) 15.9% 6.7%
Second- or third-degree heart block 4.7% 4.7%
First-degree heart block (P-R ≥ 0.26 sec) 5.3% 1.9%
Heart failure 27.5% 29.6%

Respiratory: Dyspnea of pulmonary origin has been reported in fewer than 1 of 100 patients.

Gastrointestinal: Nausea and abdominal pain have been reported in fewer than 1 of 100 patients.

Dermatologic: Rash and worsened psoriasis have been reported, but a drug relationship is not clear.

Miscellaneous: Unstable diabetes and claudication have been reported, but a drug relationship is not clear.

Potential Adverse Reactions

A variety of adverse reactions not listed above have been reported with other beta-adrenergic blocking agents and should be considered potential adverse reactions to Lopressor.

Central Nervous System: Reversible mental depression progressing to catatonia; an acute reversible syndrome characterized by disorientation for time and place, short-term memory loss, emotional lability, slightly clouded sensorium, and decreased performance on neuropsychometrics.

Cardiovascular: Intensification of AV block (see CONTRAINDICATIONS).

Hematologic: Agranulocytosis, nonthrombocytopenic purpura, and thrombocytopenic purpura.

Hypersensitive Reactions: Fever combined with aching and sore throat, laryngospasm, and respiratory distress.

Postmarketing Experience

The following adverse reactions have been reported during postapproval use of Lopressor: confusional state, an increase in blood triglycerides and a decrease in High Density Lipoprotein (HDL). Because these reports are from a population of uncertain size and are subject to confounding factors, it is not possible to reliably estimate their frequency.

Read the entire FDA prescribing information for Lopressor (Metoprolol Tartrate)

© Lopressor Patient Information is supplied by Cerner Multum, Inc. and Lopressor Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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