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Lovenox vs. Xarelto

Medical and Pharmacy Editor:

Are Xarelto and Lovenox the Same Thing?

Lovenox (enoxaparin sodium) and Xarelto (rivaroxaban) are blood thinners (anticoagulants) used to prevent blood clots that are sometimes called deep vein thrombosis (DVT), which can lead to blood clots in the lungs.

Lovenox is also used to prevent blood vessel complications in people with certain types of angina (chest pain) or heart attacks called non-Q-wave myocardial infarction or ST-segment elevation myocardial infarction.

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What Are Possible Side Effects of Lovenox?

Common side effects of Lovenox include:

  • nausea,
  • diarrhea,
  • fever,
  • swelling in your hands or feet, or
  • injection site reactions (swelling, pain, bruising, or redness).

What Are Possible Side Effects of Xarelto?

Common side effects of Xarelto include:

  • bleeding complications, including major bleeding events.

Other side effects of Xarelto include:

  • fainting,
  • itching,
  • pain in your arms or legs,
  • muscle pain, and
  • muscle spasms.

Xarelto side effects that are severe are spinal hematomas that may develop after spinal surgery with this drug.

What is Lovenox?

Lovenox (enoxaparin sodium) Injection is an anticoagulant (blood thinner) used to prevent blood clots that are sometimes called deep vein thrombosis (DVT), which can lead to blood clots in the lungs. A DVT can occur after certain types of surgery, or in people who are bed-ridden due to a prolonged illness. Lovenox is also used to prevent blood vessel complications in people with certain types of angina (chest pain) or heart attacks called non-Q-wave myocardial infarction or ST-segment elevation myocardial infarction.

What is Xarelto?

Xarelto (rivaroxaban) is a Factor Xa inhibitor indicated for the prevention of deep vein thrombosis which may lead to pulmonary embolism in patients undergoing knee or hip replacement surgery.

What Drugs Interact With Lovenox?

Lovenox may interact with aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), and other medicines to prevent blood clots.

Lovenox may also interact with dextran.

What Drugs Interact With Xarelto?

Xarelto may also interact with dexamethasone, barbiturates, seizure medications, and medicines to treat narcolepsy.

How Should Lovenox Be Taken?

The recommended dose of Lovenox for most patients is 5 mg taken orally twice daily.

The recommended dose of Lovenox is 2.5 mg twice daily in patients with at least two of the following characteristics:

  • age ≥ 80 years
  • body weight ≤ 60 kg
  • serum creatinine ≥ 1.5 mg/dL

How Should Xarelto Be Taken?

Dose of Lovenox depends on the condition of the patient and the type of surgery being performed.

Reviewed on 7/11/2018

References:

Sanofi-aventis. Lovenox Product Information.

https://www.lovenox.com/

Janssen. Xarelto Product Information.

https://www.xarelto-us.com

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