Loxitane Side Effects Center

Last updated on RxList: 5/10/2022
Loxitane Side Effects Center

What Is Loxitane?

Loxitane (loxapine succinate) Capsule is an antipsychotic medication used to treat schizophrenia. Loxitane is available in generic form.

What Are Side Effects of Loxitane?

Common side effects of Loxitane include:

  • dizziness,
  • drowsiness,
  • faintness,
  • blurred vision,
  • puffiness in your face,
  • feeling restless or agitated,
  • weakness,
  • sleep problems (insomnia),
  • breast swelling or discharge,
  • changes in menstrual periods,
  • nausea,
  • vomiting,
  • constipation,
  • changes in weight,
  • dry mouth,
  • increased saliva,
  • stuffy nose,
  • skin rash, itching, or flaking

Dosage for Loxitane

The recommended dosage of Loxitane is 10 mg twice a day.

What Drugs, Substances, or Supplements Interact with Loxitane?

Atreza, Pamine, bronchodilators, Robinul, Cantil, bladder and urinary medications, and irritable bowel medications may interact with Loxitane. Tell your doctor all medications you take. Do not drive, use machinery, or do any activity that requires alertness when taking Loxitane. Avoid drinking alcohol while taking Loxitane.

Loxitane During Pregnancy or Breastfeeding

Do not take Loxitane if you are pregnant or breastfeeding.

Additional Information

Our Loxitane (loxapine succinate) Capsule Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

QUESTION

Schizophrenia is the most disabling mental illness. See Answer
Loxitane Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

High doses or long-term use of loxapine can cause a serious movement disorder that may not be reversible. The longer you use loxapine, the more likely you are to develop this disorder, especially if you are a woman or an older adult.

Call your doctor at once if you have:

  • uncontrolled muscle movements in your arms or legs, or your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);
  • fast heart rate;
  • a light-headed feeling, like you might pass out;
  • confusion, slurred speech;
  • agitation, trouble sleeping;
  • seizure (convulsions);
  • little or no urinating;
  • severe constipation;
  • low white blood cell counts--fever, chills, mouth sores, skin sores, sore throat, cough, trouble breathing, feeling light-headed; or
  • severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Common side effects may include:

  • dizziness, problems with balance or walking;
  • swelling in your face;
  • itching or rash;
  • tremors, muscle twitching or stiffness;
  • numbness, weakness;
  • blurred vision;
  • feeling restless or agitated;
  • nausea, vomiting, constipation;
  • dry mouth, stuffy nose; or
  • insomnia.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Loxitane (Loxapine)

SLIDESHOW

Schizophrenia: Symptoms, Types, Causes, Treatment See Slideshow
Loxitane Professional Information

SIDE EFFECTS

CNS Effects

Manifestations of adverse effects on the central nervous system, other than extrapyramidal effects, have been seen infrequently. Drowsiness, usually mild, may occur at the beginning of therapy or when dosage is increased. It usually subsides with continued LOXITANE therapy. The incidence of sedation has been less than that of certain aliphatic phenothiazines and slightly more than the piperazine phenothiazines. Dizziness, faintness, staggering gait, shuffling gait, muscle twitching, weakness, insomnia, agitation, tension, seizures, akinesia, slurred speech, numbness, and confusional states have been reported. Neuroleptic malignant syndrome (NMS) has been reported (see WARNINGS).

Extrapyramidal Symptoms - Neuromuscular (extrapyramidal) reactions during the administration of LOXITANE have been reported frequently, open during the first few days of treatment. In most patients, these reactions involved parkinsonian-like symptoms such as tremor, rigidity, excessive salivation, and masked facies. Akathisia (motor restlessness) also has been reported relatively frequently. These symptoms are usually not severe and can be controlled by reduction of LOXITANE dosage or by administration of antiparkinson drugs in usual dosage.

Dystonia - Class effect

Symptoms of dystonia, prolonged abnormal contractions of muscle groups, may occur in susceptible individuals during the first few days of treatment. Dystonic symptoms include: spasm of the neck muscles, sometimes progressing to tightness of the throat, swallowing difficulty, difficulty breathing, and/or protrusion of the tongue. While these symptoms can occur at low doses, they occur more frequently and with greater severity with high potency and at higher doses of first generation antipsychotic drugs. An elevated risk of acute dystonia is observed in males and younger age groups.

Persistent Tardive Dyskinesia - As with all antipsychotic agents, tardive dyskinesia may appear in some patients on long-term therapy or may appear after drug therapy has been discontinued. The risk appears to be greater in elderly patients on high-dose therapy, especially females. The symptoms are persistent and in some patients appear to be irreversible. The syndrome is characterized by rhythmical involuntary movement of the tongue, face, mouth or jaw (e.g., protrusion of tongue, puffing of cheeks, puckering of mouth, chewing movements). Sometimes these may be accompanied by involuntary movements of extremities.

There is no known effective treatment for tardive dyskinesia; antiparkinson agents usually do not alleviate the symptoms of this syndrome. It is suggested that all antipsychotic agents be discontinued if these symptoms appear. Should it be necessary to reinstitute treatment, or increase the dosage of the agent, or switch to a different antipsychotic agent, the syndrome may be masked. It has been suggested that fine vermicular movements of the tongue may be an early sign of the syndrome, and if the medication is stopped at that time the syndrome may not develop.

Cardiovascular Effects

Tachycardia, hypotension, hypertension, orthostatic hypotension, lightheadedness, and syncope have been reported.

A few cases of ECG changes similar to those seen with phenothiazines have been reported. It is not known whether these were related to LOXITANE administration.

Hematologic

Rarely, agranulocytosis, thrombocytopenia, leukopenia.

Skin

Dermatitis, edema (puffiness of face), pruritus, rash, alopecia, and seborrhea have been reported with loxapine.

Anticholinergic Effects

Dry mouth, nasal congestion, constipation, blurred vision, urinary retention, and paralytic ileus have occurred.

Gastrointestinal

Nausea and vomiting have been reported in some patients. Hepatocellular injury (i.e., SGOT/SGPT elevation) has been reported in association with loxapine administration and rarely, jaundice and/or hepatitis questionably related to LOXITANE treatment.

Other Adverse Reactions

Weight gain, weight loss, dyspnea, ptosis, hyperpyrexia, flushed facies, headache, paresthesia, and polydipsia have been reported in some patients. Rarely, galactorrhea, amenorrhea, gynecomastia, and menstrual irregularity of uncertain etiology have been reported.

Read the entire FDA prescribing information for Loxitane (Loxapine)

© Loxitane Patient Information is supplied by Cerner Multum, Inc. and Loxitane Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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