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Last reviewed on RxList: 1/20/2005
Lufyllin Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 5/27/2016

Lufyllin (dyphylline) is a bronchodilator used to treat the symptoms of asthma, bronchitis, and emphysema. Common side effects include:

  • stomach pain/cramping
  • nausea
  • vomiting
  • diarrhea
  • loss of appetite
  • headache
  • trouble sleeping (insomnia)
  • rritability
  • restlessness
  • nervousness
  • shaking
  • flushing
  • increased urination
  • weight loss
  • tremor
  • lightheadedness, or
  • dizziness

The usual adult dosage of Lufyllin is up to 15 mg/kg every six hours. Lufyllin may interact with alcohol, cimetidine, antibiotics, disulfiram, estrogens, fluvoxamine, methotrexate, mexiletine and propafenone, propranolol, tacrine, ticlopidine, verapamil, aminoglutethimide, carbamazepine, isoproterenol, moricizine, phenobarbital, phenytoin, rifampin, and sucralfate. Tell your doctor all medications and supplements you use. During pregnancy, Lufyllin should be used only if prescribed. This drug passes into breast milk and may have undesirable effects on a nursing infant (e.g., irritability). Consult your doctor before breastfeeding.

Our Lufyllin (dyphylline) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Lufyllin Consumer Information

If you experience any of the following serious side effects, stop taking dyphylline and seek emergency medical attention:

  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
  • seizures;
  • increased or irregular heartbeats; or
  • severe nausea or vomiting.

Other, less serious side effects may occur although they are not common at appropriate doses. Continue to take dyphylline and talk to your doctor if you experience

  • slight nausea, decreased appetite, or weight loss;
  • restlessness, tremor, or insomnia; or
  • headache, lightheadedness, or dizziness.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Lufyllin (Dyphylline)

Lufyllin Professional Information


Adverse reactions with the use of LUFYLLIN (dyphylline) have been infrequent, relatively mild, and rarely required reduction in dosage or withdrawal of therapy.

The following adverse reactions which have been reported with other xanthine bronchodilators, and which have most often been related to excessive drug plasma levels, should be considered as potential adverse effects when dyphylline is administered:

Gastrointestinal:   nausea, vomiting, epigastric pain, hematemesis, diarrhea.

Central nervous system:   headache, irritability, restlessness, insomnia, hyperexcitability, agitation, muscle twitching, generalized clonic and tonic convulsions.

Cardiovascular:   palpitation, tachycardia, extrasystoles, flushing, hypotension, circulatory failure, ventricular arrhythmias.

Respiratory:   tachypnea.

Renal:   albuminuria, gross and microscopic hematuria, diuresis.

Other:   hyperglycemia, inappropriate ADH syndrome.

Read the entire FDA prescribing information for Lufyllin (Dyphylline)

Related Resources for Lufyllin

© Lufyllin Patient Information is supplied by Cerner Multum, Inc. and Lufyllin Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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