Slideshows Images Quizzes

Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. See additional information.


Last reviewed on RxList: 5/22/2017
Lysodren Side Effects Center

Last reviewed on RxList 05/23/2017

Lysodren (mitotane) is an antineoplastic (anticancer) medication used to treat cancer of the adrenal gland (adrenal cortical carcinoma). Common side effects of Lysodren include:

Tell your doctor if you have serious side effects of Lysodren including:

  • severe dizziness,
  • flushing,
  • fast or pounding heartbeat,
  • shakiness (tremors),
  • unusual or rapid weight loss,
  • change in skin color or thickness,
  • easy bleeding or bruising,
  • breast tenderness or enlargement (males),
  • unwanted facial or body hair (females),
  • mental/mood changes (e.g., depression, irritability, difficulty concentrating, confusion),
  • speech problems,
  • numbness or tingling of hands or feet,
  • unsteadiness,
  • pink urine, or
  • vision problems.

The recommended initial dose of Lysodren is 2 to 6 g per day in divided doses, either three or four times a day. Doses are usually increased incrementally to 9 to 10 g per day. Lysodren may interact with other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety), blood thinners, or spironolactone. Tell your doctor all medications you use. During pregnancy, Lysodren should be used only when prescribed. It is unknown if this drug passes into breast milk and could have undesirable effects on a nursing infant. Breastfeeding is not recommended while using this drug.

Our Lysodren (mitotane) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Skin Cancer Symptoms, Types, Images See Slideshow
Lysodren Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • blurred or double vision;
  • confusion, problems with speech, balance, or walking;
  • a light-headed feeling, like you might pass out;
  • pelvic pain, vaginal bleeding;
  • easy bruising or bleeding (nosebleeds, bleeding gums); or
  • any bleeding that will not stop.

Common side effects may include:

  • nausea, vomiting, loss of appetite;
  • diarrhea;
  • drowsiness;
  • depressed mood, weakness, lack of energy;
  • dizziness, spinning sensation; or
  • mild skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Lysodren (Mitotane)

Lysodren Professional Information


The following adverse reactions are discussed in greater detail in other sections of the label:

The following adverse reactions associated with the use of LYSODREN were identified in clinical trials or postmarketing reports. Because these reactions were reported voluntarily from a population of uncertain size, it is not always possible to estimate their frequency reliably or to establish a causal relationship to drug exposure.

Common adverse reactions occurring with LYSODREN treatment include:

Less common adverse reactions include: visual blurring, diplopia, lens opacity, retinopathy, prolonged bleeding time, hematuria, hemorrhagic cystitis, albuminuria, hypertension, orthostatic hypotension, flushing, generalized aching, and fever.

Read the entire FDA prescribing information for Lysodren (Mitotane)

Related Resources for Lysodren

Related Health

Related Drugs

Read the Lysodren User Reviews »

© Lysodren Patient Information is supplied by Cerner Multum, Inc. and Lysodren Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.


Skin Cancer Symptoms, Types, Images See Slideshow

Health Solutions From Our Sponsors