Macrodantin vs. Amoxil (Amoxicillin)

Are Macrodantin and Amoxil (Amoxicillin) the Same Thing?

Macrodantin (nitrofurantoin) and Amoxil (Amoxicillin) (amoxicillin) are antibiotics prescribed to treat or prevent urinary tract infections.

Amoxil (Amoxicillin) is also used to treat infections of the skin, lungs, and eye, ears, nose, and throat.

Macrodantin and Amoxil (Amoxicillin) are different types of antibiotics. Macrodantin is a nitrofuran antibiotic and Amoxil (Amoxicillin) is a penicillin antibiotic.

Side effects of Macrodantin and Amoxil (Amoxicillin) that are similar include headache, rash, nausea, vomiting, diarrhea, and vaginal itching or discharge.

Side effects of Macrodantin that are different from Amoxil (Amoxicillin) include itching, upset stomach, loss of appetite, and rust-colored or brownish urine.

Side effects of Amoxil (Amoxicillin) that are different from Macrodantin include stomach pain and swollen, black, or "hairy" tongue.

Both Macrodantin and Amoxil (Amoxicillin) may interact with probenecid.

Macrodantin may also interact with antacids, magnesium salicylate, and choline magnesium salicylate.

Amoxil (Amoxicillin) may also interact with blood thinners, other antibiotics, or sulfa drugs.

What Are Possible Side Effects of Macrodantin?

Side effects of Macrodantin include:

  • headache,
  • itching,
  • rash,
  • nausea,
  • upset stomach,
  • vomiting,
  • loss of appetite,
  • diarrhea,
  • rust-colored or brownish urine, or
  • vaginal itching or discharge.

What Are Possible Side Effects of Amoxil (Amoxicillin)?

Common side effects of Amoxil (Amoxicillin) include:

  • mild headache (not a migraine),
  • pain or chest tightness,
  • pressure or heavy feeling in any part of your body,
  • weakness,
  • feeling hot or cold,
  • dizziness,
  • spinning sensation,
  • drowsiness,
  • nausea,
  • vomiting,
  • drooling,
  • unusual taste in your mouth after using nasal spray,
  • burning/numbness/pain/irritation in your nose or throat after using nasal spray, or
  • flushing (warmth, redness, or tingling under the skin).

What Is Macrodantin?

Macrodantin (nitrofurantoin) is an antibiotic prescribed to treat or prevent urinary tract infections. Macrodantin is available in generic form.

What Is Amoxil (Amoxicillin)?

Amoxil (amoxicillin) is a penicillin-type antibiotic used to treat infections caused by bacteria that are B-lactamase negative (B-lactamase positive bacteria are usually resistant to Amoxil (amoxicillin)); these infections usually occur in the skin, lungs, urinary tract and eye, ears, nose, and throat. Amoxil (amoxicillin) is available as a generic drug termed amoxicillin. Amoxil (amoxicillin) may be combined with other drugs (for example, clavulanic acid [Augmentin]), to make the antibiotic more effective.


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What Drugs Interact With Macrodantin?

Macrobid may also interact with magnesium salicylate or choline magnesium salicylate.

What Drugs Interact With Amoxil (Amoxicillin)?

Amoxil (amoxicillin) may interact with probenecid, blood thinners, other antibiotics, or sulfa drugs. Tell your doctor all medications and supplements you use. Treatment in pregnant women and women who are breastfeeding should be done with caution.

How Should Macrodantin Be Taken?

Macrodantin should be given with food to improve drug absorption and, in some patients, tolerance. Adults should take 50-100 mg four times a day-the lower dosage level is recommended for uncomplicated urinary tract infections.

How Should Amoxil (Amoxicillin) Be Taken?

Amoxil (amoxicillin) is available in many preparations (capsules, tablets, chewable tablets, powder for oral suspension and pediatric oral suspension).


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DailyMed. Macrodantin Product Information.
DailyMed. Amoxil (amoxicillin) Product Information.

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