Macrodantin vs. Bactrim

Reviewed on 8/2/2019

Are Macrodantin and Bactrim the Same Thing?

Macrodantin (nitrofurantoin) and Bactrim (sulfamethoxazole and trimethoprim) are antibiotics prescribed to treat or prevent urinary tract infections.

Bactrim is also used to treat middle ear infection (acute otitis media), bronchitis, Shigellosis, Pneumocystis pneumonia, traveler's diarrhea, methicillin-resistant Staphylococcus aureus (MRSA), and other bacterial infections.

Macrodantin and Bactrim are different types of antibiotics. Macrodantin is a nitrofuran antibiotic and Bactrim is a combination of a sulfonamide antibiotic (a “sulfa” drug) and a dihydrofolate reductase inhibitor.

Side effects of Macrodantin and Bactrim that are similar include nausea, vomiting, and loss of appetite.

Side effects of Macrodantin that are different from Bactrim include headache, itching, rash, upset stomach, diarrhea, rust-colored or brownish urine, and vaginal itching or discharge.

Side effects of Bactrim that are different from Macrodantin include painful or swollen tongue, dizziness, spinning sensation, ringing in your ears, tiredness, and sleep problems (insomnia).

Macrodantin may interact with antacids, magnesium salicylate, choline magnesium salicylate, and probenecid.

Bactrim may also interact with leucovorin and methotrexate.

What Are Possible Side Effects of Macrodantin?

Side effects of Macrodantin include:

  • headache,
  • itching,
  • rash,
  • nausea,
  • upset stomach,
  • vomiting,
  • loss of appetite,
  • diarrhea,
  • rust-colored or brownish urine, or
  • vaginal itching or discharge.

What Are Possible Side Effects of Bactrim?

Common side effects of Bactrim include:

  • loss of appetite,
  • nausea,
  • vomiting,
  • painful or swollen tongue,
  • dizziness,
  • spinning sensation,
  • ringing in your ears,
  • tiredness, or
  • sleep problems (insomnia).

Tell your doctor if you experience serious side effects of Bactrim including:

What Is Macrodantin?

Macrodantin (nitrofurantoin) is an antibiotic prescribed to treat or prevent urinary tract infections. Macrodantin is available in generic form.

What Is Bactrim?

Bactrim (sulfamethoxazole and trimethoprim) DS is a combination of two antibiotics used to treat urinary tract infections, acute otitis media, bronchitis, Shigellosis, Pneumocystis pneumonia, traveler's diarrhea, methicillin-resistant Staphylococcus aureus (MRSA), and other bacterial infections susceptible to this antibiotic. Bactrim is available as a generic drug.

QUESTION

How much urine does the average adult pass each day? See Answer

What Drugs Interact With Macrodantin?

Macrobid may also interact with magnesium salicylate or choline magnesium salicylate.

What Drugs Interact With Bactrim?

Bactrim may interact with blood thinners, cyclosporine, methotrexate, oral diabetes medications, and seizure medications.

Bactrim may also interact with antidepressants, digoxin, diuretics (water pills), indomethacin, leucovorin, calcium folinate, and heart or blood pressure medications.

How Should Macrodantin Be Taken?

Macrodantin should be given with food to improve drug absorption and, in some patients, tolerance. Adults should take 50-100 mg four times a day-the lower dosage level is recommended for uncomplicated urinary tract infections.

How Should Bactrim Be Taken?

Administer the solution by intravenous infusion over a period of 60 to 90 minutes. Avoid administration by rapid infusion or bolus injection. Do NOT administer Bactrim intramuscularly.

SLIDESHOW

Urinary Incontinence in Women: Types, Causes, and Treatments for Bladder Control See Slideshow
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References

DailyMed. Macrodantin Product Information.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=89d8696b-f9ce-9691-6222-8416ca143bba
FDA. Bactrim Product Information.
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/017377s068s073lbl.pdf

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