Macrodantin vs. Primsol

Are Macrodantin and Primsol the Same Thing?

Macrodantin (nitrofurantoin) and Primsol (trimethoprim hydrochloride oral solution) are antibiotics prescribed to treat or prevent urinary tract infections.

Primsol is also used to treat middle ear infections (acute otitis media).

Macrodantin and Primsol are different types of antibiotics. Macrodantin is a nitrofuran antibiotic Primsol is an aminopyrimidine antibiotic.

Side effects of Macrodantin and Primsol that are similar include rash, vomiting, and diarrhea.

Side effects of Macrodantin that are different from Primsol include headache, itching, nausea, upset stomach, loss of appetite, rust-colored or brownish urine, and vaginal itching or discharge.

Side effects of Primsol that are different from Macrodantin include abdominal pain.

Macrodantin may interact with antacids, magnesium salicylate, choline magnesium salicylate, and probenecid.

Primsol may interact with phenytoin.

What Are Possible Side Effects of Macrodantin?

Side effects of Macrodantin include:

  • headache,
  • itching,
  • rash,
  • nausea,
  • upset stomach,
  • vomiting,
  • loss of appetite,
  • diarrhea,
  • rust-colored or brownish urine, or
  • vaginal itching or discharge.

What Are Possible Side Effects of Primsol?

Common side effects of Primsol include:

What Is Macrodantin?

Macrodantin (nitrofurantoin) is an antibiotic prescribed to treat or prevent urinary tract infections. Macrodantin is available in generic form.

What Is Primsol?

Primsol (trimethoprim hydrochloride oral solution) is an antibacterial solution indicated for the treatment of infections caused by susceptible strains of the designated microorganisms in the following conditions: acute otitis media due to susceptible strains of Streptococcus pneumoniae and Haemophilus influenza, and treatment of initial episodes of uncomplicated urinary tract infections due to susceptible strains of: Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Enterobacter species and coagulase-negative Staphylococcus species, including S. saprophyticus.


How much urine does the average adult pass each day? See Answer

What Drugs Interact With Macrodantin?

Macrobid may also interact with magnesium salicylate or choline magnesium salicylate.

What Drugs Interact With Primsol?

Primsol may interact with phenytoin. Tell your doctor all medications and supplements you use. During pregnancy, Primsol should be taken only if prescribed. Primsol may interfere with folic acid metabolism. Primsol passes into breast milk and may interfere with folic acid metabolism. Consult your doctor before breastfeeding.

How Should Macrodantin Be Taken?

Macrodantin should be given with food to improve drug absorption and, in some patients, tolerance. Adults should take 50-100 mg four times a day-the lower dosage level is recommended for uncomplicated urinary tract infections.

How Should Primsol Be Taken?

The recommended dose of Primsol for pediatric patients with acute otitis media is 10 mg/kg trimethoprim per 24 hours, given in divided doses every 12 hours for 10 days. The usual oral adult dosage of Primsol to treat urinary tract infections is 100 mg (10 mL) every 12 hours or 200 mg (20 mL) every 24 hours, each for 10 days.


Urinary Incontinence in Women: Types, Causes, and Treatments for Bladder Control See Slideshow

All drug information provided on is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, makes every effort to update its drug information. Due to the time-sensitive nature of drug information, makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the or websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.


DailyMed. Macrodantin Product Information.
Dailymed. Primsol Product Information.

Health Solutions From Our Sponsors