Mandol Side Effects Center

Last updated on RxList: 8/11/2022
Mandol Side Effects Center

What Is Mandol?

Mandol (cefamandole) is an antibiotic used to treat serious infections caused by susceptible strains of certain microorganisms. The brand name Mandol is discontinued, but generic versions may be available.

What Are Side Effects of Mandol?

Common side effects of Mandol (cefamandole) include:

Less common side effects of Mandol (cefamandole) include:

Mandol may cause serious side effects including:

  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • severe dizziness,
  • fatigue,
  • nausea,
  • decreased appetite,
  • mild fever,
  • mild abdominal pain,
  • yellowing of the skin or eyes (jaundice),
  • low blood platelet count,
  • low white blood cell count, and
  • pain at the injection site

Get medical help right away, if you have any of the symptoms listed above.

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Mandol

The usual adult dosage range of Mandol is 500 mg to 1 g every 4 to 8 hours.

What Drugs, Substances, or Supplements Interact with Mandol?

Mandol may interact with other drugs. Tell your doctor all medications and supplements you use.

Mandol During Pregnancy or Breastfeeding

Tell your doctor if you are pregnant or become pregnant during treatment with Mandol. Consult your doctor before breastfeeding.

Additional Information

Our Mandol (cefamandole) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Mandol Professional Information


Gastrointestinal  Symptoms of pseudomembranous colitis may appear either during or after antibiotic treatment. Nausea and vomiting have been reported rarely. As with some penicillins and some other cephalosporins, transient hepatitis and cholestatic jaundice have been reported rarely.

Hypersensitivity  Anaphylaxis, maculopapular rash, urticaria, eosinophilia, and drug fever have been reported. These reactions are more likely to occur in patients with a history of allergy, particularly to penicillin.

Blood  Thrombocytopenia has been reported rarely. Neutropenia has been reported, especially in long courses of treatment. Some individuals have developed positive direct Coombs' tests during treatment with the cephalosporin antibiotics.

Liver  Transient rise in SGOT, SGPT, and alkaline phosphatase levels has been noted.

Kidney  Decreased creatinine clearance has been reported in patients with prior renal impairment. As with some other cephalosporins, transitory elevations of BUN have occasionally been observed with Mandol (cefamandole) ; their frequency increases in patients over 50 years of age. In some of these cases, there was also a mild increase in serum creatinine.

Local Reactions  Pain on intramuscular injection is infrequent. Thrombophlebitis occurs rarely.


Read the entire FDA prescribing information for Mandol (Cefamandole)


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© Mandol Patient Information is supplied by Cerner Multum, Inc. and Mandol Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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