Reviewed on 9/23/2021

What Is Manganese and How Does It Work?

Manganese is a mineral that is found in several foods including nuts, legumes, seeds, tea, whole grains, and leafy green vegetables. It is considered an essential nutrient, because the body requires it to function properly. People use manganese as medicine.

Manganese is used for prevention and treatment of manganese deficiency, a condition in which the body doesn't have enough manganese. It is also used for weak bones (osteoporosis), a type of "tired blood" (anemia), and symptoms of premenstrual syndrome (PMS).

Manganese is sometimes included with chondroitin sulfate and glucosamine hydrochloride in multi-ingredient products promoted for osteoarthritis.

Manganese is available under the following different brand names: MnC12

Dosages of Manganese


  • 10 mg (elemental)
  • 15 mg (elemental)
  • 93 mg (aspartate; 25 mg elemental)
  • 50 mg (gluconate; 5.7 mg elemental)


  • 16.67 mg
  • 50 mg

Injectable Solution (adult and pediatric)

  • 0.1 mg/ml

What Are Side Effects Associated with Using Manganese?

There are no documented side effects of manganese.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Manganese?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.

What Are Warnings and Precautions for Manganese?


  • This medication contains manganese
  • Do not take MnC12 if you are allergic to manganese or any ingredients contained in this drug
  • Keep out of reach of children
  • In case of overdose, get medical help or contact a Poison Control Center immediately


  • Direct intravenous or intramuscular injection administration (must dilute)

Effects of Drug Abuse

  • No information available

Short-Term Effects

  • See "What Are Side Effects Associated with Using Manganese?"

Long-Term Effects

  • See "What Are Side Effects Associated with Using Manganese?"


  • May cause tissue damage if administered intravenously or intramuscularly directly due to very acidic solution (pH 2.0)
  • Injection contains aluminum; use caution in renal impairment and premature infants
  • Use caution in liver/biliary tract dysfunction, renal impairment (may need to decrease or withhold dose)

Pregnancy and Lactation

  • Use manganese during pregnancy with caution if benefits outweigh risks
  • Animal studies show risk and human studies are not available, or neither animal nor human studies were done
Medscape. Manganese.
RxList. Manganese.

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