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Mannitol vs. Lasix

Reviewed on 7/9/2019

Are Mannitol and Lasix the Same Thing?

Mannitol injection and Lasix (furosemide) are diuretics used to treat renal (kidney) failure and other conditions.

Mannitol is also used to increase urine production, and to treat or prevent medical conditions caused by an increase in body fluids/water (e.g., cerebral edema, glaucoma).

Lasix is also used to treat excessive fluid accumulation (edema) caused by congestive heart failure, liver failure, and nephritic syndrome. Lasix may be used with antihypertensive drugs to control high blood pressure (hypertension).

Side effects of mannitol and Lasix that are similar include diarrhea, thirst, and dizziness.

Side effects of mannitol that are different from Lasix include headache, nausea, vomiting, dry mouth, dehydration, blurred vision, runny nose, arm pain, chills, low blood pressure (hypotension), hives, irregular heart beat, electrolyte imbalance, and injection site reactions (irritation, pain, swelling).

Side effects of Lasix that are different from mannitol include increased urination, muscle cramps, itching or rash, weakness, spinning sensation, stomach pain, and constipation.

Mannitol may interact with other drugs.

Lasix may interact with sucralfate, cisplatin, cyclosporine, ethacrynic acid, lithium, methotrexate, phenytoin, antibiotics, heart or blood pressure medications, laxatives, salicylates such as aspirin, or steroids.

What Are Possible Side Effects of Mannitol?

Common side effects of Mannitol include:

  • headache,
  • nausea,
  • diarrhea,
  • vomiting,
  • dry mouth,
  • thirst,
  • dehydration,
  • blurred vision,
  • nausea,
  • vomiting,
  • runny nose,
  • arm pain,
  • chills,
  • dizziness,
  • low blood pressure (hypotension),
  • hives,
  • irregular heart beat,
  • electrolyte imbalance, and
  • irritation/pain/swelling at the injection site.

What Are Possible Side Effects of Lasix?

Common side effects of Lasix include:

  • increased urination,
  • thirst,
  • muscle cramps,
  • itching or rash,
  • weakness,
  • dizziness,
  • spinning sensation,
  • diarrhea,
  • stomach pain, and
  • constipation.

Serious side effects of Lasix include:

  • dehydration,
  • dark urine,
  • clay-colored stools,
  • nausea,
  • vomiting,
  • fever,
  • jaundice (yellowing of skin or eyes),
  • electrolyte abnormalities,
  • loss of appetite, and
  • rapid weight loss.

What Is Mannitol?

Mannitol I.V. (mannitol injection) is a diuretic used to increase urine production, and to treat or prevent medical conditions that are caused by an increase in body fluids/water (e.g., cerebral edema, glaucoma, kidney failure).

What Is Lasix?

Lasix (furosemide) is an anthranilic acid derivative that is used as a strong diuretic in adults and children to treat excessive fluid accumulation (edema) caused by congestive heart failure, liver failure, renal failure, and nephritic syndrome. Lasix may be used with antihypertensive drugs to control high blood pressure (hypertension).

QUESTION

The only purpose of the kidneys is to filter blood. See Answer

What Drugs Interact With Mannitol?

Mannitol may interact with other drugs. Tell your doctor all medications and supplements you use.

What Drugs Interact With Lasix?

Lasix may interact with lithium or steroids.

Lasix may also interact with sucralfate, cisplatin, cyclosporine, ethacrynic acid, methotrexate, phenytoin, antibiotics, heart or blood pressure medications, laxatives, or salicylates such as aspirin.

How Should Mannitol Be Taken?

The usual adult dosage of Mannitol ranges from 50 to 200 g in a 24-hour period, but in most instances an adequate response will be achieved at a dosage of approximately 100 g/24 hours.

How Should Lasix Be Taken?

Lasix is available in tablet (20 to 80 mg) and IV forms. Dosage is determined by the patient's physician and varies according to how much fluid and how fast the fluid should be removed. Patients with poor renal function usually require higher doses; doses in children are weight-based. Lasix may interact with sucralfate, cisplatin, cyclosporine, ethacrynic acid, lithium, methotrexate, phenytoin, antibiotics, heart or blood pressure medications, laxatives, salicylates such as aspirin, or steroids. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant while using Lasix; it is unknown if it will harm a fetus. Lasix passes into breast milk and may harm a nursing baby. Lasix may also slow breast milk production. Consult your doctor before breastfeeding.

SLIDESHOW

Kidney Stones: Symptoms, Causes, and Treatment See Slideshow
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References


DailyMed. Mannitol Product Information.

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d12cc802-b538-4065-a264-f474ff3b3043


FDA. Lasix Product Information.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/016273s066lbl.pdf
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