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Last reviewed on RxList: 10/4/2018
Matulane Side Effects Center

Last reviewed on RxList 10/4/2018

Matulane (procarbazine hydrochloride) Capsules is a cancer medication that is given with other cancer medications to treat Hodgkin's Disease (a type of blood cancer). Common side effects of Matulane include:

  • nausea and vomiting (may be severe),
  • loss of appetite,
  • stomach pain,
  • constipation,
  • dry mouth,
  • diarrhea,
  • difficulty swallowing,
  • drowsiness,
  • tiredness,
  • dizziness,
  • headache,
  • trouble sleeping,
  • muscle or joint pain,
  • temporary hair loss,
  • darkening of the skin,
  • itching or rash,
  • urinating more than usual, or
  • changes in your menstrual periods

All dosages of Matulane are based on the patient's actual weight. The recommended adult starting dose of Matulane is single or divided doses of 2 to 4 mg/kg/day for the first week. Matulane may interact with blood pressure medications, antidepressants, barbiturates, diet pills, stimulants, or ADHD medications, phenothiazines, or other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). Tell your doctor all medications and supplements you use. Matulane is not recommended for use during pregnancy. It may harm a fetus. It is recommended that men and women use 2 forms of birth control (e.g., condoms and birth control pills) while being treated with this medication and for some time afterward. Consult your doctor to discuss birth control. It is unknown if this drug passes into breast milk. Because this drug may harm a nursing infant, breastfeeding while using this drug is not recommended.

Our Matulane (procarbazine hydrochloride) Capsules Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Matulane Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • diarrhea that is watery;
  • a light-headed feeling, like you might pass out;
  • numbness, burning pain, or tingly feeling;
  • confusion, hallucinations, problems with vision or speech, trouble with walking or daily activities;
  • feeling unsteady, loss of balance or coordination;
  • tremors, seizure (convulsions);
  • cough, chest pain, trouble breathing;
  • fever, chills, body aches, flu symptoms;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • white patches or sores inside your mouth or on your lips;
  • jaundice (yellowing of the skin or eyes); or
  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds.

Common side effects may include:

  • mild nausea, vomiting, loss of appetite, stomach pain;
  • dry mouth, constipation, mild diarrhea;
  • mild itching or rash, temporary hair loss;
  • muscle of joint pain;
  • headache, dizziness, feeling tired;
  • urinating more than usual; or
  • changes in your menstrual periods.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Matulane (Procarbazine)

Matulane Professional Information


Leukopenia, anemia and thrombopenia occur frequently. Nausea and vomiting are the most commonly reported side effects.

Other adverse reactions are:


Pancytopenia; eosinophilia; hemolytic anemia; bleeding tendencies such as petechiae, purpura, epistaxis and hemoptysis.


Hepatic dysfunction, jaundice, stomatitis, hematemesis, melena, diarrhea, dysphagia, anorexia, abdominal pain, constipation, dry mouth.


Coma, convulsions, neuropathy, ataxia, paresthesia, nystagmus, diminished reflexes, falling, foot drop, headache, dizziness, unsteadiness.


Hypotension, tachycardia, syncope.


Retinal hemorrhage, papilledema, photophobia, diplopia, inability to focus.


Pneumonitis, pleural effusion, cough.


Herpes, dermatitis, pruritus, alopecia, hyperpigmentation, rash, urticaria, flushing.


Generalized allergic reactions.


Hematuria, urinary frequency, nocturia.


Pain, including myalgia and arthralgia; tremors.


Hallucinations, depression, apprehension, nervousness, confusion, nightmares.


Gynecomastia in prepubertal and early pubertal boys.


Intercurrent infections, hearing loss, pyrexia, diaphoresis, lethargy, weakness, fatigue, edema, chills, insomnia, slurred speech, hoarseness, drowsiness.

Second nonlymphoid malignancies (including lung cancer, acute myelocytic leukemia and malignant myelosclerosis) and azoospermia have been reported in patients with Hodgkin's disease treated with procarbazine in combination with other chemotherapy and/or radiation. The risks of secondary lung cancer from treatment appear to be multiplied by tobacco use.

Read the entire FDA prescribing information for Matulane (Procarbazine)

Related Resources for Matulane

© Matulane Patient Information is supplied by Cerner Multum, Inc. and Matulane Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.


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