Last updated on RxList: 3/18/2021
Matulane Side Effects Center

What Is Matulane?

Matulane (procarbazine hydrochloride) Capsules is a cancer medication that is given with other cancer medications to treat Hodgkin's Disease (a type of blood cancer).

What Are Side Effects of Matulane?

Common side effects of Matulane include:

  • nausea and vomiting (may be severe),
  • loss of appetite,
  • stomach pain,
  • constipation,
  • dry mouth,
  • diarrhea,
  • difficulty swallowing,
  • drowsiness,
  • tiredness,
  • dizziness,
  • headache,
  • trouble sleeping,
  • muscle or joint pain,
  • temporary hair loss,
  • darkening of the skin,
  • itching or rash,
  • urinating more than usual, or
  • changes in your menstrual periods

Dosage for Matulane

All dosages of Matulane are based on the patient's actual weight. The recommended adult starting dose of Matulane is single or divided doses of 2 to 4 mg/kg/day for the first week.

What Drugs, Substances, or Supplements Interact with Matulane?

Matulane may interact with blood pressure medications, antidepressants, barbiturates, diet pills, stimulants, or ADHD medications, phenothiazines, or other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). Tell your doctor all medications and supplements you use.

Matulane During Pregnancy and Breastfeeding

Matulane is not recommended for use during pregnancy. It may harm a fetus. It is recommended that men and women use 2 forms of birth control (e.g., condoms and birth control pills) while being treated with this medication and for some time afterward. Consult your doctor to discuss birth control. It is unknown if this drug passes into breast milk. Because this drug may harm a nursing infant, breastfeeding while using this drug is not recommended.

Additional Information

Our Matulane (procarbazine hydrochloride) Capsules Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Matulane Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • diarrhea that is watery;
  • numbness, burning pain, or tingly feeling;
  • confusion, hallucinations, problems with vision or speech, trouble with walking or daily activities;
  • feeling unsteady, loss of balance or coordination;
  • tremors, seizure;
  • cough, chest pain, trouble breathing;
  • blisters or ulcers in your mouth, red or swollen gums, trouble swallowing;
  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • liver problems--loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
  • low blood cell counts--fever, chills, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.

Common side effects may include:

  • low blood cell counts; or
  • nausea, vomiting.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Matulane (Procarbazine)

Matulane Professional Information


Leukopenia, anemia and thrombopenia occur frequently. Nausea and vomiting are the most commonly reported side effects.

Other adverse reactions are:


Pancytopenia; eosinophilia; hemolytic anemia; bleeding tendencies such as petechiae, purpura, epistaxis and hemoptysis.


Hepatic dysfunction, jaundice, stomatitis, hematemesis, melena, diarrhea, dysphagia, anorexia, abdominal pain, constipation, dry mouth.


Coma, convulsions, neuropathy, ataxia, paresthesia, nystagmus, diminished reflexes, falling, foot drop, headache, dizziness, unsteadiness.


Hypotension, tachycardia, syncope.


Retinal hemorrhage, papilledema, photophobia, diplopia, inability to focus.


Pneumonitis, pleural effusion, cough.


Herpes, dermatitis, pruritus, alopecia, hyperpigmentation, rash, urticaria, flushing.


Generalized allergic reactions.


Hematuria, urinary frequency, nocturia.


Pain, including myalgia and arthralgia; tremors.


Hallucinations, depression, apprehension, nervousness, confusion, nightmares.


Gynecomastia in prepubertal and early pubertal boys.


Intercurrent infections, hearing loss, pyrexia, diaphoresis, lethargy, weakness, fatigue, edema, chills, insomnia, slurred speech, hoarseness, drowsiness.

Second nonlymphoid malignancies (including lung cancer, acute myelocytic leukemia and malignant myelosclerosis) and azoospermia have been reported in patients with Hodgkin's disease treated with procarbazine in combination with other chemotherapy and/or radiation. The risks of secondary lung cancer from treatment appear to be multiplied by tobacco use.


See WARNINGS section.

No cross-resistance with other chemotherapeutic agents, radiotherapy or steroids has been demonstrated.

Read the entire FDA prescribing information for Matulane (Procarbazine)

© Matulane Patient Information is supplied by Cerner Multum, Inc. and Matulane Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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