Last updated on RxList: 9/30/2020
Maxide Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Maxzide?

Maxzide (triamterene and hydrochlorothiazide) is a combination of a potassium-conserving diuretic and a natriuretic agent and is prescribed as a treatment for hypertension (high blood pressure) and edema. Maxzide is also a diuretic given to patients who cannot risk low blood potassium. Maxzide may be used alone or in combination with other antihypertensive drugs, such as beta-blockers but dosages may need to be adjusted; regardless, potassium levels in patients is recommended for all patients taking Maxzide. Maxzide is available in generic form.

What Are Side Effects of Maxzide?

Common side effects of Maxzide include:

  • dizziness,
  • lightheadedness,
  • headache, or upset stomach as your body adjusts to the medication

Other side effects of Maxzide include:

  • nausea,
  • diarrhea,
  • constipation,
  • fatigue,
  • headache,
  • insomnia, and
  • dry mouth

Tell your doctor if you experience rare but serious side effects including fainting, muscle cramps/weakness, slow/fast/irregular heartbeat, decrease in vision, eye pain, signs of kidney problems (such as change in the amount of urine), or symptoms of a serious allergic reaction (rash, itching/swelling, especially of the face/tongue/throat, severe dizziness, trouble breathing

Dosage for Maxzide?

Maxzide has two preparations based on the strengths of the two components; triamterene and hydrochlorothiazide at concentrations of 37.5 and 25 mg or 75 and 50 mg, respectively. The usual dose of Maxzide is 25mg based on the hydrochlorothiazide concentration, one or two tablets daily, given as a single dose. Divided daily doses, (rather than a single daily dose, and not recommend by the supplier) may place patients at an increased risk of electrolyte imbalance and kidney dysfunction.

What Drugs, Substances, or Supplements Interact with Maxzide?

The routine use of this and other diuretics in an otherwise healthy pregnant woman to reduce minor dependent edema or in an attempt to prevent toxemia of pregnancy is inappropriate and exposes mother and fetus to unnecessary hazards.

Maxzide During Pregnancy and Breastfeeding

The safe use of Maxzide in pregnancy has not been established and the effect of Maxzide in pregnant women has not been studied. Maxzide should be used during pregnancy only if the potential benefit justifies the risk to the fetus. If use of Maxzide is deemed essential, breastfeeding mothers should stop nursing because some of the drug is found in breast milk. Maxzide has not been studied in children.

Additional Information

Our Maxzide (triamterene and hydrochlorothiazide) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Maxide Consumer Information

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Stop taking this medicine and call your doctor at once if you have:

  • blurred vision, tunnel vision, eye pain, or seeing halos around lights;
  • a light-headed feeling, like you might pass out;
  • fast, slow, or uneven heart rate;
  • signs of liver or pancreas problems--loss of appetite, upper stomach pain (that may spread to your back), nausea or vomiting, fast heart rate, dark urine, jaundice (yellowing of the skin or eyes);
  • high potassium level--nausea, weakness, tingly feeling, feeling weak or tired, slow heartbeats, loss of movement;
  • low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling;
  • kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath;
  • lupus-like symptoms--muscle or joint pain, flu symptoms, chest pain, and a rash or patchy skin color that worsens in sunlight; or
  • other signs of an electrolyte imbalance--thirst, dry mouth, stomach pain, drowsiness, weakness, fast heart rate, muscle pain or weakness, feeling restless or light-headed.

Common side effects may include:

  • stomach pain, nausea, diarrhea, constipation;
  • dizziness, headache;
  • blurred vision; or
  • dry mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Maxide (Triamterene and Hydrochlorothiazide Tablets)


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Maxide Professional Information


Side effects observed in association with the use of MAXZIDE, other combination products containing triamterene/hydrochlorothiazide, and products containing triamterene or hydrochlorothiazide include the following:

Gastrointestinal: jaundice (intrahepatic cholestatic jaundice), pancreatitis, nausea, appetite disturbance, taste alteration, vomiting, diarrhea, constipation, anorexia, gastric irritation, cramping.

Central Nervous System: drowsiness and fatigue, insomnia, headache, dizziness, dry mouth, depression, anxiety, vertigo, restlessness, paresthesias.

Cardiovascular: tachycardia, shortness of breath and chest pain, orthostatic hypotension (may be aggravated by alcohol, barbiturates or narcotics).

Renal: acute renal failure, acute interstitial nephritis, renal stones composed of triamterene in association with other calculus materials, urine discoloration.

Hematologic: leukopenia, agranulocytosis, thrombocytopenia, aplastic anemia, hemolytic anemia and megaloblastosis.

Ophthalmic: xanthopsia, transient blurred vision.

Hypersensitivity: anaphylaxis, photosensitivity, rash, urticaria, purpura, necrotizing angiitis (vasculitis, cutaneous vasculitis), fever, respiratory distress including pneumonitis.

Other: muscle cramps and weakness, decreased sexual performance and sialadenitis.

Whenever adverse reactions are moderate to severe, therapy should be reduced or withdrawn.

Altered Laboratory Findings

Serum Electrolytes: hyperkalemia, hypokalemia, hyponatremia, hypomagnesemia, hypochloremia (see WARNINGS AND PRECAUTIONS).

Creatinine, Blood Urea Nitrogen: Reversible elevations in BUN and serum creatinine have been observed in hypertensive patients treated with MAXZIDE.

Glucose: hyperglycemia, glycosuria and diabetes mellitus (see PRECAUTIONS).

Serum Uric Acid, PBI and Calcium: (see PRECAUTIONS).

Other: Elevated liver enzymes have been reported in patients receiving MAXZIDE.

Postmarketing Experience

Non-melanoma Skin Cancer

Hydrochlorothiazide is associated with an increased risk of non-melanoma skin cancer. In a study conducted in the Sentinel System, increased risk was predominantly for squamous cell carcinoma (SCC) and in white patients taking large cumulative doses. The increased risk for SCC in the overall population was approximately 1 additional case per 16,000 patients per year, and for white patients taking a cumulative dose of ≥ 50,000 mg the risk increase was approximately 1 additional SCC case for every 6,700 patients per year.

Read the entire FDA prescribing information for Maxide (Triamterene and Hydrochlorothiazide Tablets)

© Maxide Patient Information is supplied by Cerner Multum, Inc. and Maxide Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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