Mayzent vs. Plegridy

Are Mayzent and Plegridy the Same Thing?

Mayzent (siponimod) and Plegridy (peginterferon beta-1a) Autoinjector are used to treat relapsing forms of multiple sclerosis (MS).

Mayzent and Plegridy belong to different drug classes. Mayzent is a sphingosine 1-phosphate receptor modulator and Plegridy is a beta interferon.

Side effects of Mayzent and Plegridy that are similar include headache and nausea.

Side effects of Mayzent that are different from Plegridy include high blood pressure (hypertension), increased liver transaminase, falls, pain and swelling in extremities, dizziness, diarrhea, and slow heart rate.

Side effects of Plegridy that are different from Mayzent include injection site reactions (redness, itching, pain, swelling, warmth, rash, bruising), flu-like illness, fever, muscle or joint pain, chills, weakness, and vomiting.

Mayzent may interact with "live" vaccines, cancer medications, immune-modulating drugs, immunosuppressive therapies, anti-arrhythmics, QT prolonging drugs, calcium channel blockers, other drugs that may decrease heart rate, beta-blockers, fluconazole, rifampin, carbamazepine, modafinil, and efavirenz.

Plegridy may interact with other drugs.

What Are Possible Side Effects of Mayzent?

Common side effects of Mayzent include:

  • headache,
  • high blood pressure (hypertension),
  • increased transaminase,
  • falls,
  • swelling of extremities,
  • nausea,
  • dizziness,
  • diarrhea,
  • slow heart rate, and
  • pain in extremities

What Are Possible Side Effects of Plegridy?

Common side effects of Plegridy include:

  • injection site reactions (redness, itching, pain, swelling, warmth, rash, bruising),
  • flu-like illness,
  • fever,
  • headache,
  • muscle or joint pain,
  • chills,
  • weakness,
  • nausea, and
  • vomiting

What Is Mayzent?

Mayzent (siponimod) is a sphingosine 1-phosphate receptor modulator indicated for the treatment of relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.

What Is Plegridy?

Plegridy (peginterferon beta-1a) Autoinjector is an interferon beta-1a used to treat patients with relapsing forms of multiple sclerosis.

QUESTION

What kind of disease is multiple sclerosis? See Answer

What Drugs Interact With Mayzent?

Mayzent may interact with:

  • "live" vaccines,
  • cancer medications,
  • immune-modulating drugs,
  • immunosuppressive therapies,
  • anti-arrhythmics,
  • QT prolonging drugs,
  • calcium channel blockers,
  • other drugs that may decrease heart rate,
  • beta-blockers,
  • fluconazole,
  • rifampin,
  • carbamazepine,
  • modafinil, or
  • efavirenz.

What Drugs Interact With Plegridy?

Tell your doctor all medications and supplements you use. During pregnancy, Plegridy should be used only if prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

How Should Mayzent Be Taken?

Initiate Mayzent with a 5-day titration. The recommended maintenance dosage of Mayzent is 2 mg.

How Should Plegridy Be Taken?

The recommended dosage of Plegridy is 125 micrograms injected subcutaneously every 14 days.

SLIDESHOW

What Is Multiple Sclerosis? MS Symptoms, Causes, Diagnosis See Slideshow
Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References
Novartis AG. Mayzent Product Information.

https://www.mayzent.com

Biogen. Plegridy Product Information

www.plegridy.com/?

Health Solutions From Our Sponsors