Mayzent vs. Rebif

• Are Mayzent and Rebif the Same Thing?
• What Are Possible Side Effects of Mayzent?
• What Are Possible Side Effects of Rebif?
• What Is Mayzent?
• What Is Rebif?
• What Drugs Interact with Mayzent?
• What Drugs Interact with Rebif?
• How Should Mayzent Be Taken?
• How Should Rebif Be Taken?

Mayzent (siponimod) and Rebif (interferon beta-1a) Injection are used to treat relapsing forms of multiple sclerosis (MS).

Mayzent and Rebif belong to different drug classes. Mayzent is a sphingosine 1-phosphate receptor modulator and Rebif is a beta interferon.

Side effects of Mayzent and Rebif that are similar include headache and dizziness.

Side effects of Mayzent that are different from Rebif include high blood pressure (hypertension), increased liver transaminase, falls, pain and swelling in extremities, nausea, diarrhea, and slow heart rate.

Side effects of Rebif that are different from Mayzent include injection site reactions (pain, swelling, or redness), flu-like symptoms (such as fatigue, fever, chills, stomach pain, runny or stuffy nose, and muscle aches), and depression.

Both Mayzent and Rebif may interact with cancer medications, seizure medications, cholesterol-lowering medications, and heart or blood pressure medications.

Mayzent may also interact with "live" vaccines, immune-modulating drugs, immunosuppressive therapies, anti-arrhythmics, QT prolonging drugs, other drugs that may decrease heart rate, fluconazole, rifampin, modafinil, and efavirenz.

Rebif may also interact with alcohol, acetaminophen, aspirin, gout or arthritis medications (including gold injections), nonsteroidal anti-inflammatory drugs (NSAIDs), antibiotics, antifungals, sulfa drugs,

Common side effects of Mayzent include:

• headache,
• high blood pressure (hypertension),
• increased transaminase,
• falls,
• swelling of extremities,
• nausea,
• dizziness,
• diarrhea,
• slow heart rate, and
• pain in extremities

Common side effects of Rebif include pain, swelling, or redness at the injection site. Flu-like symptoms such as headache, dizziness, fatigue, fever, chills, stomach pain, runny or stuffy nose, and muscle aches may occur when you first start Rebif. These symptoms usually improve or go away after a few months of continued use of Rebif. Some patients using interferon medications such as Rebif become depressed or have suicidal thoughts. Tell your doctor immediately if this occurs. Tell your doctor if you have serious side effects of Rebif including:

• mental/mood changes (e.g., depression, rare thoughts of suicide),
• vision changes,
• gradual change in weight,
• intolerance to cold or heat,
• increased urination,
• pus or change in skin color at the injection site,
• signs of infection (e.g., fever, persistent sore throat, cough),
• easy bruising or bleeding,
• fast or irregular heartbeat,
• sudden increase in weight,
• swelling hands/legs/feet,
• severe stomach or abdominal pain,
• yellowing eyes or skin, or
• dark urine.

Mayzent (siponimod) is a sphingosine 1-phosphate receptor modulator indicated for the treatment of relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.

Rebif (interferon beta-1a) Injection is made from human proteins and is used to treat relapsing multiple sclerosis (MS). Rebif will not cure MS; it will only decrease the frequency of relapse symptoms. Common side effects of Rebif include pain, swelling, or redness at the injection site. Flu-like symptoms such as headache, dizziness, fatigue, fever, chills, stomach pain, runny or stuffy nose, and muscle aches may occur when you first start Rebif. These symptoms usually improve or go away after a few months of continued use of Rebif. Some patients using interferon medications such as Rebif become depressed or have suicidal thoughts. Tell your doctor immediately if this occurs.

Mayzent may interact with:

• "live" vaccines,
• cancer medications,
• immune-modulating drugs,
• immunosuppressive therapies,
• anti-arrhythmics,
• QT prolonging drugs,
• calcium channel blockers,
• other drugs that may decrease heart rate,
• beta-blockers,
• fluconazole,
• rifampin,
• carbamazepine,
• modafinil, or
• efavirenz.

Rebif may interact with other drugs. Tell your doctor all medications and supplements you take. Talk to your doctor about how to drink alcohol safely while using this medication. Rebif should not be used during pregnancy. Talk to your doctor if you are pregnant or think you might become pregnant during treatment. Consult your doctor before breastfeeding.

Initiate Mayzent with a 5-day titration. The recommended maintenance dosage of Mayzent is 2 mg.

The recommended dosage of Rebif is 22 mcg to 44 mcg injected subcutaneously three times per week. Rebif is intended for use under the supervision of a physician. Patients may self-inject only after proper training.