Medrol vs. Prelone

Are Medrol and Prelone the Same Thing?

Medrol (methylprednisolone) and Prelone (prednisolone syrup) are corticosteroids used to treat or manage many conditions, including arthritis and other rheumatic disorders, skin and eye conditions, blood disorders, cancers, allergies, and respiratory diseases, among others.

What Are Possible Side Effects of Medrol?

Common side effects of Medrol include:

  • skin problems (acne, dry and thinning skin, easy bruising or discoloration),
  • slow wound healing,
  • changes in the shape or location of body fat (especially in the neck, face, arms, legs, breasts, and waist),
  • nausea,
  • stomach pain,
  • bloating,
  • headache,
  • dizziness,
  • spinning sensation,
  • sleep problems (insomnia),
  • increased sweating, and
  • mood changes.

Serious side effects of Medrol include emergency medical conditions such as:

What Are Possible Side Effects of Prelone?

Common side effects of Prelone include:

  • nausea,
  • stomach pain or upset,
  • bloating,
  • heartburn,
  • increased appetite,
  • headache,
  • dizziness,
  • spinning sensation,
  • menstrual period changes,
  • trouble sleeping (insomnia),
  • mood changes,
  • increased sweating, or
  • acne.

Prelone may infrequently make your blood sugar level rise, which can cause or worsen diabetes. Tell your doctor if you have unlikely but serious side effects of Prelone including:

  • unusual tiredness,
  • swelling ankles or feet,
  • unusual weight gain,
  • vision problems,
  • easy bruising or bleeding,
  • puffy face,
  • unusual hair growth,
  • muscle weakness or pain,
  • thinning skin,
  • slow wound healing, or
  • bone pain.

What is Medrol?

Medrol (methylprednisolone) is a glucocorticoid (adrenocortical steroid) that can depress the immune response and inflammation and is used in diseases ranging from rheumatologic, hematologic, endocrine, dermatologic, immunologic, allergic, and ophthalmologic to many others.

What is Prelone?

Prelone (prednisolone syrup) is an adrenocortical steroid used to treat conditions such as arthritis, blood problems, immune system disorders, skin and eye conditions, breathing problems, cancer, and severe allergies.

What Drugs Interact With Medrol?

Medrol may interact with aspirin (taken on a daily basis or at high doses), diuretics (water pills), blood thinner, cyclosporine, insulin or oral diabetes medications, ketoconazole, rifampin, seizure medications, or "live" vaccines. Tell your doctor all medications and supplements you use and all vaccines you recently received.

What Drugs Interact With Prelone?

Prelone may interact with aldesleukin, other drugs that weaken the immune system (such as azathioprine, cyclosporine, cancer chemotherapy, natalizumab), large doses of aspirin and salicylates, nonsteroidal anti-inflammatory drugs (NSAIDs), mifepristone, amphotericin B, diuretics, antibiotics, blood thinners, antiplatelet drugs, estrogens, azole antifungals, rifamycins, St. John's wort, or drugs used to treat seizures. Tell your doctor all medications and supplements you use.

How Should Medrol Be Taken?

Medrol is available as 2, 4, 8, 16 or 32 mg strength tablets. Dosages are extremely variable and are based on what diseases are being treated.

How Should Prelone Be Taken?

The initial dosage of Prelone Syrup varies from 5 mg to 60 mg per day depending on the disease being treated.


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Pfizer. Medrol Product Information.

DailyMed. Prelone/Flo-Pred Product Information.

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