Mestinon Side Effects Center

Last updated on RxList: 5/4/2022
Mestinon Side Effects Center

What Is Mestinon?

Mestinon (pyridostigmine) is a cholinesterase inhibitor used to treat the symptoms of myasthenia gravis. Mestinon is also used in military personnel who have been exposed to nerve gas. Mestinon is available in generic form.

What Are Side Effects of Mestinon?

Common side effects of Mestinon include:

  • nausea,
  • vomiting,
  • upset stomach,
  • diarrhea,
  • abdominal cramps,
  • increased saliva/mucus,
  • decreased pupil size,
  • increased urination,
  • increased sweating or cold sweat,
  • pale skin,
  • watery eyes,
  • warmth or tingly feeling, or
  • rash or itching.

Tell your doctor if you have unlikely but serious side effects of Mestinon including:

  • new or increased muscle cramps/weakness/twitching,
  • shortness of breath,
  • new or increased difficulty swallowing,
  • slow heartbeat,
  • dizziness, or
  • headache.

Dosage for Mestinon

Mestinon is available in syrup, conventional tablets, and timespan (slow-release) tablets. Dose is adjusted for each patient. For syrup and conventional tablets, the average dose is ten 60 mg tablets or ten 5 mL teaspoonfuls daily. The dose for timespan tablets is one to three 180 mg tablets, once or twice daily.

What Drugs, Substances, or Supplements Interact with Mestinon?

Mestinon may interact with atropine, belladonna, clidinium, dicyclomine, glycopyrrolate, hyoscyamine, mepenzolate, methantheline, methscopolamine, propantheline, scopolamine, antibiotics, or heart rhythm medications. Tell your doctor all medications you are taking.

Mestinon During Pregnancy and Breastfeeding

During pregnancy, Mestinon should be used only when prescribed. It is not known whether this medication passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Mestinon (pyridostigmine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Mestinon Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using pyridostigmine and call your doctor at once if you have any of these serious side effects:

  • extreme muscle weakness;
  • loss of movement in any part of your body;
  • weak or shallow breathing;
  • slurred speech, vision problems; or
  • worsening or no improvement in your symptoms of myasthenia gravis.

Common side effects may include:

  • stomach pain, nausea, vomiting, diarrhea;
  • muscle cramps, twitching;
  • sweating, increased salivation;
  • cough with mucus;
  • rash; or
  • blurred vision.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Mestinon Professional Information


The side effects of MESTINON are most commonly related to overdosage and generally are of two varieties, muscarinic and nicotinic. Among those in the former group are nausea, vomiting, diarrhea, abdominal cramps, increased peristalsis, increased salivation, increased bronchial secretions, miosis and diaphoresis. Nicotinic side effects are comprised chiefly of muscle cramps, fasciculation and weakness. Muscarinic side effects can usually be counteracted by atropine, but for reasons shown in the preceding section the expedient is not without danger. As with any compound containing the bromide radical, a skin rash may be seen in an occasional patient. Such reactions usually subside promptly upon discontinuance of the medication.

To report SUSPECTED ADVERSE REACTIONS, contact Bausch Health US, LLC at 1-800-321-4576 or FDA at 1-800-FDA-1088 or


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Read the entire FDA prescribing information for Mestinon (Pyridostigmine)

© Mestinon Patient Information is supplied by Cerner Multum, Inc. and Mestinon Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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