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Methadose

Last reviewed on RxList: 8/2/2019
Methadose Side Effects Center

Last reviewed on RxList 8/2/2019

Methadose is indicated to relieve moderate to severe pain that has not been relieved by non-narcotic pain relievers. Methadose also is used to prevent withdrawal symptoms in patients who were addicted to opiate drugs and are enrolled in treatment programs. Side effects of Methadose include:

  • drowsiness,
  • weakness,
  • dizziness,
  • nausea,
  • vomiting,
  • constipation,
  • lack of appetite,
  • stomach pain,
  • sweating,
  • dry mouth,
  • flushing,
  • anxiety,
  • nervousness,
  • restlessness,
  • sleep problems (insomnia),
  • diarrhea,
  • decreased sex drive,
  • impotence, or
  • difficulty having an orgasm

Methadose comes as a tablet, a dispersible tablet (can be dissolved in liquid), a solution (liquid), and a concentrated solution (liquid that must be diluted before use) to take by mouth. Methadose can be taken with or without food as prescribed by a doctor. Many other drugs can interact with Methadose. Tell your doctor all medications you use. During pregnancy, Methadose should be used only when clearly needed. Using it for long periods or in high doses near the expected delivery date is not recommended because of possible harm to the fetus. Methadose passes into breast milk and is unlikely to harm a nursing infant. Women who are planning to breastfeed should consult their doctors before doing so. If breastfeeding is suddenly stopped, the nursing infant may experience withdrawal symptoms. Breastfeeding women should discuss a plan for breastfeeding with their doctors. It is not known if Methadose can cause fetal harm when administered to a pregnant or breastfeeding woman. Withdrawal symptoms may occur if you suddenly stop using this medication.

Our Methadose Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

QUESTION

Medically speaking, the term "myalgia" refers to what type of pain? See Answer
Methadose Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

Call your doctor at once if you have:

  • weak or shallow breathing, breathing that stops during sleep;
  • severe constipation;
  • a light-headed feeling, like you might pass out;
  • fast or pounding heartbeats, fluttering in your chest, shortness of breath; or
  • low cortisol levels--nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Serious side effects may be more likely in older adults and those who are malnourished or debilitated.

Long-term use of opioid medication may affect fertility (ability to have children) in men or women. It is not known whether opioid effects on fertility are permanent.

Common side effects may include:

  • dizziness, drowsiness;
  • nausea, vomiting;
  • increased sweating; or
  • pain, redness, or swelling where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Methadose (Methadone Hydrochloride Tablets)

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Methadose Professional Information

SIDE EFFECTS

The following serious adverse reactions and/or conditions are discussed elsewhere in the labeling:

The major hazards of methadone are respiratory depression and, to a lesser degree, systemic hypotension. Respiratory arrest, shock, cardiac arrest, and death have occurred.

The most frequently observed adverse reactions include lightheadedness, dizziness, sedation, nausea, vomiting, and sweating. These effects seem to be more prominent in ambulatory patients and in those who are not suffering severe pain. In such individuals, lower doses are advisable.

Other adverse reactions include the following:

Body as a Whole: asthenia (weakness), edema, headache

Cardiovascular: arrhythmias, bigeminal rhythms, bradycardia, cardiomyopathy, ECG abnormalities, extrasystoles, flushing, heart failure, hypotension, palpitations, phlebitis, QT interval prolongation, syncope, T-wave inversion, tachycardia, torsades de pointes, ventricular fibrillation, ventricular tachycardia

Central Nervous System: agitation, confusion, disorientation, dysphoria, euphoria, insomnia, hallucinations, seizures, visual disturbances

Endocrine: hypogonadism

Gastrointestinal: abdominal pain, anorexia, biliary tract spasm, constipation, dry mouth, glossitis

Hematologic: reversible thrombocytopenia has been described in opioid addicts with chronic hepatitis

Metabolic: hypokalemia, hypomagnesemia, weight gain

Renal: antidiuretic effect, urinary retention or hesitancy

Reproductive: amenorrhea, reduced libido and/or potency, reduced ejaculate volume, reduced seminal vesicle and prostate secretions, decreased sperm motility, abnormalities in sperm morphology

Respiratory: pulmonary edema, respiratory depression

Skin and Subcutaneous Tissue: pruritus, urticaria, other skin rashes, and rarely, hemorrhagic urticaria

Hypersensitivity: Anaphylaxis has been reported with ingredients contained in Methadose. Advise patients how to recognize such a reaction and when to seek medical attention.

Maintenance on a Stabilized Dose: During prolonged administration of methadone, as in a methadone maintenance treatment program, constipation and sweating often persist and hypogonadism, decreased serum testosterone and reproductive effects are thought to be related to chronic opioid use.

Methadose for the Detoxification and Maintenance Treatment of Opioid Dependence

During the induction phase of methadone maintenance treatment, patients are being withdrawn from illicit opioids and may have opioid withdrawal symptoms. Monitor patients for signs and symptoms including: lacrimation, rhinorrhea, sneezing, yawning, excessive perspiration, goose-flesh, fever, chilling alternating with flushing, restlessness, irritability, weakness, anxiety, depression, dilated pupils, tremors, tachycardia, abdominal cramps, body aches, involuntary twitching and kicking movements, anorexia, nausea, vomiting, diarrhea, intestinal spasms, and weight loss and consider dose adjustment as indicated.

Read the entire FDA prescribing information for Methadose (Methadone Hydrochloride Tablets)

Related Resources for Methadose

© Methadose Patient Information is supplied by Cerner Multum, Inc. and Methadose Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

QUESTION

Medically speaking, the term "myalgia" refers to what type of pain? See Answer

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