Medical Editor: John P. Cunha, DO, FACOEP
What Is Methitest?
Methitest (methyltestosterone) is an androgen, a male hormone, indicated for replacement therapy in conditions associated with a deficiency or absence of endogenous testosterone such as primary hypogonadism (congenital or acquired) and hypogonadotropic hypogonadism (congenital or acquired) in males, and to treat advancing inoperable metastatic (skeletal) mammary cancer in females who are 1 to 5 years postmenopausal.
What Are Side Effects of Methitest?
Common side effects of Methitest include:
- changes in skin color
- ankle swelling
- frequent or persistent erections of the penis and breast enlargement in men, and,
- in women, hoarseness, acne, changes in menstrual periods, or more hair on the face
Dosage for Methitest
In the androgen-deficient male the guideline for replacement therapy indicates the usual initial dosage of 10-50 mg Methitest daily. Guideline dosages of androgens for use in the palliative treatment of women with metastatic breast cancer are 50-200 mg daily.
What Drugs, Substances, or Supplements Interact with Methitest?
Methitest may interact with anticoagulants, oxyphenbutazone, and insulin. Tell your doctor all medications and supplements you use.
Methitest During Pregnancy and Breastfeeding
Methitest is not recommended for use during pregnancy or while breastfeeding.
Our Methitest (methyltestosterone) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- changes in skin color;
- increased or ongoing erection of the penis;
- shortness of breath (even with mild exertion);
- swelling, rapid weight gain; or
- liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Women using methyltestosterone may develop male characteristics, which could be irreversible if treatment is continued. Stop using this medicine and call your doctor at once if you notice any of these signs of excess testosterone:
- changes in menstrual periods;
- male-pattern hair growth (such as on the chin or chest);
- hoarse or deepened voice; or
- enlarged clitoris.
Common side effects (in men or women) may include:
- breast swelling;
- headache, anxiety, depressed mood;
- numbness or tingly feeling; or
- increased or decreased interest in sex.
Read the entire detailed patient monograph for Methitest (Methyltestosterone Tablets, USP)
Endocrine And Urogenital
Female: The most common side effects of androgen therapy are amenorrhea and other menstrual irregularities, inhibition of gonadotropin secretion, and virilization, including deepening of the voice and clitoral enlargement. The latter usually is not reversible after androgens are discontinued. When administered to a pregnant woman, androgens cause virilization of external genitalia of the female fetus.
Male: Gynecomastia, and excessive frequency and duration of penile erections. Oligospermia may occur at high dosage (see CLINICAL PHARMACOLOGY).
Skin and Appendages: Hirsutism, male pattern of baldness, and acne.
Cardiovascular Disorders: Myocardial infarction, stroke
Fluid and Electrolyte Disturbances: Retention of sodium, chloride, water, potassium, calcium, and inorganic phosphates.
Gastrointestinal: Nausea, cholestatic jaundice, alterations in liver function tests, rarely hepatocellular neoplasma and peliosis hepatis (see WARNINGS).
Hematologic: Suppression of clotting factors II, V, VII, and X, bleeding in patients on concomitant anticoagulant therapy, and polycythemia.
Nervous System: Increased or decreased libido, headache, anxiety, depression, and generalized paresthesia.
Metabolic: Increased serum cholesterol.
Vascular Disorders: Venous thromboembolism.
Miscellaneous: Rarely, anaphylactoid reactions.
To report SUSPECTED ADVERSE REACTIONS, contact Amneal Pharmaceuticals at 1-877-835-5472 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Read the entire FDA prescribing information for Methitest (Methyltestosterone Tablets, USP)
© Methitest Patient Information is supplied by Cerner Multum, Inc. and Methitest Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.