Methoxylated Flavones

Reviewed on 6/11/2021
Other Name(s):

5-Methyl-7-Methoxy Isoflavone, 5,6,7,8,4'-pentamethoxyflavone, 5,6,7,3',4'-pentamethoxyflavone, 5,6,7,8,3',4'-hexamethoxyflavone, 3,5,6,7,8,3',4'-heptamethoxyflavone, Bioflavonoid, Bioflavonoïde, Bioflavonoid Complex, Bioflavonoid Concentrate, Bioflavonoid Extract, Citrus Bioflavones, Citrus Bioflavonoid Extract, Citrus Bioflavonoid, Citrus Bioflavonoids, Citrus Flavones, Citrus Flavonoids, Citrus Polymethoxylated Flavones, Complexe de Bioflavonoïde, Concentré de Bioflavonoïde, Extrait de Bioflavonoïde, Flavonas Metoxiladas, Flavones Méthoxylées, Flavonoids, Flavonoïdes, Flavonoïdes Méthoxylés, Gardenin D, Heptamethoxyflavones, Hexamethoxyflavones, Methoxyflavones, Méthoxyflavones, Methoxylated flavonoids, Nobiletin, Nobilétine, Pentamethoxyflavones, PMF, Polyméthoxyflavones, Polymethoxylated Flavones, Sinensetin, Sinensétine, Tangeretin, Tangerétine, Tetramethoxyflavones.


Flavonoids are pigments found in plants. They are responsible for many of the yellow, red, and orange colors in plants.

Over 4000 different flavonoids have been identified from various plant sources. Common food sources include red wine, stems, flowers, fruits, vegetables, nuts, seeds, herbs, spices, coffee, and teas.

In 1936, some scientists suggested that flavonoids be recognized as vitamins. They believed that flavonoids were necessary to protect the health of capillaries, the smallest blood vessels. But there wasn't enough evidence to justify classifying flavonoids as vitamins.

Flavonoids are divided into groups based on slight differences in chemical structure. Flavones are one of the groups. Methoxylated flavones are a subdivision of that group. Methoxylated flavones are found in especially large amounts in citrus fruits.

Methoxylated flavones are used for poor circulation in the legs (venous insufficiency), varicose veins, heart disease, high cholesterol, cataracts, and cancer.

How does it work?

Methoxylated flavones are natural antioxidants and might reduce inflammation (swelling). They might also affect the way the liver processes cholesterol and other blood fats. Scientists think methoxylated flavones might also reduce the spread of cancer cells. But more information is needed.


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Uses & Effectiveness

Insufficient Evidence to Rate Effectiveness for...

  • Poor circulation in the legs (venous insufficiency).
  • Varicose veins.
  • Heart disease.
  • High cholesterol.
  • Cataracts.
  • Cancer.
  • Other conditions.
More evidence is needed to rate the effectiveness of methoxylated flavones for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

Side Effects

Methoxylated flavones are a normal part of the diet. They are safe when consumed as part of food. But there isn't enough information available to know if supplements containing methoxylated flavones are safe.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Methoxylated flavones are safe for pregnant and breast-feeding women when used as part of the diet. But the safety of methoxylated flavones during pregnancy and breast-feeding is not known when used in amounts greater than those commonly found in foods. It's best to stay on the safe side and limit intake to food amounts.

Surgery: Methoxylated flavones can slow blood clotting. There is some concern that they might increase the risk of bleeding during and after surgery. Stop taking methoxylated flavones supplements at least 2 weeks before a scheduled surgery.


Next to red peppers, you can get the most vitamin C from ________________. See Answer


Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Some medications are changed and broken down by the liver. Methoxylated flavones might increase how quickly the liver breaks down some medications. Taking methoxylated flavones along with some medications that are changed by the liver might decrease the effects of some medications. Before taking methoxylated flavones, talk to your healthcare provider if you take any medications that are changed by the liver.

Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others.

Medications moved by pumps in cells (P-Glycoprotein substrates)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Some medications are moved by pumps in cells. Some methoxylated flavones might change how these pumps work and increase how much of some medications get absorbed by the body.

Some medications that are moved by these pumps include etoposide, paclitaxel, vinblastine, vincristine, vindesine, ketoconazole, itraconazole, amprenavir, indinavir, nelfinavir, saquinavir, cimetidine, ranitidine, diltiazem, verapamil, corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others.

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Some methoxylated flavones might slow blood clotting. Taking methoxylated flavones along with medications that also slow clotting might increase the chances of bruising and bleeding.

Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.


The appropriate dose of methoxylated flavones depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for methoxylated flavones. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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Kurowska EM, Manthey JA. Hypolipidemic Effects and Absorption of Citrus Polymethoxylated Flavones in Hamsters with Diet-Induced Hypercholesterolemia. J Agric Food Chem 2004;52:2879-86. View abstract.

Manthey JA, Guthrie N. Antiproliferative effects of citrus flavonoids against six human cancer cell lines. J Agric Food Chem 2002;50:5837-43. View abstract.

Middleton E, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 2000;52:673-751. View abstract.

Robbins RC. Action in human blood of methoxylated flavones which confer disease resistance on both plants and animals: Concept of a dietary conditioned mechanism of defense against disease. Internat J Vit Nutr Res 1975;45:51-60. View abstract.

Robbins RC. Effect of methoxylated flavones on erythrocyte aggregation and sedimentation in blood of normal subjects: Evidence of a dietary role for flavonoids. Internat J Vit Nutr Res 1973;43:494-503.

Robbins RC. In vitro effects of penta-, hexa-, and hepta-methoxylated flavones on aggregation of cells in blood from hospitalized patients. J Clin Pharmacol 1973;13:271-5.

Robbins RC. Specificities between blood cell adhesion in human diseases and antiadhesion action in vitro of methoxylated flavones. J Clin Pharmacol 1973;13:401-7.

Robbins RC. Stabilization of flow properties of blood with phenylbenzo-y-pyrone derivatives (Flavonoids). Internat J Vit Nutr Res 1977;47:373-82. View abstract.

Takanaga H, Ohnishi A, Yamada S, et al. Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not cytochrome P450 3A4. J Pharmacol Exp Ther 2000;293:230-6. View abstract.

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