Medical Editor: John P. Cunha, DO, FACOEP
What Is Methyldopa?
Methyldopa is an antihypertensive indicated to treat high blood pressure (hypertension). Methyldopa is available in generic form. Side effects of methyldopa tend to occur early in therapy or when a dose is increased and are temporary and mild. Common side effects of methyldopa include:
- lack of energy, or
What Are Side Effects of Methyldopa?
Dosage for Methyldopa
The usual starting dosage of methyldopa tablets is 250 mg two to three times a day in the first 48 hours. The daily dosage then may be increased or decreased, preferably at intervals of not less than 2 days, until an adequate response is achieved.
What Drugs, Substances, or Supplements Interact with Methyldopa?
Methyldopa may interact with other antihypertensive drugs, anesthetics, lithium, ferrous sulfate or ferrous gluconate, and monoamine oxidase (MAO) inhibitors. Tell your doctor all medications and supplements you use.
Methyldopa During Pregnancy and Breastfeeding
Tell your doctor if you are pregnant or plan to become pregnant before using methyldopa; it is not expected to harm a fetus. Methyldopa passes into breast milk. Consult your doctor before breastfeeding.
Our Methyldopa Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Sedation, usually transient, may occur during the initial period of therapy or whenever the dose is increased. Headache, asthenia, or weakness may be noted as early and transient symptoms. However, significant adverse effects due to methyldopa have been infrequent and this agent usually is well tolerated.
The following adverse reactions have been reported and, within each category, are listed in order of decreasing severity.
Nervous System/Psychiatric: Parkinsonism, Bell's palsy, decreased mental acuity, involuntary choreoathetotic movements, symptoms of cerebrovascular insufficiency, psychic disturbances including nightmares and reversible mild psychoses or depression, headache, sedation, asthenia or weakness, dizziness, light-headedness, paresthesias.
Metabolic: Rise in BUN.
Respiratory: Nasal stuffiness.
Skin: Toxic epidermal necrolysis, rash.
Read the entire FDA prescribing information for Methyldopa (methyldopa)