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Micronase

Last reviewed on RxList: 2/21/2017
Micronase Side Effects Center

Last reviewed on RxList 12/21/2016

Micronase (glyburide) is an oral diabetes medicine used to treat type II diabetes. Side effects of Micronase include:

Tell your doctor if you have serious side effects of Micronase including:

  • signs of infection (persistent sore throat, fever),
  • easy bleeding or bruising,
  • stomach pain,
  • yellowing eyes or skin,
  • dark urine,
  • unusual tiredness or weakness,
  • unusual or sudden weight gain,
  • mental/mood changes,
  • swelling of the hands or feet, or
  • seizures.

Micronase is taken in tablet form with breakfast or the first main meal of the day. The usual starting dose of Micronase Tablets is 2.5 to 5 mg daily. Micronase may interact with blood thinners, cyclosporine, disopyramide, azole antifungals, fluoxetine, rifampin, ACE inhibitors, antibiotics, albuterol, clonidine, reserpine, beta-blockers, isoniazid, diuretics (water pills), steroids, phenothiazines, thyroid medicine, birth control pills and other hormones, heart or blood pressure medications, niacin, seizure medicines, diet pills, medicines to treat asthma, colds or allergies, exenatide, probenecid, nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin or other salicylates (including Pepto-Bismol), sulfa drugs, monoamine oxidase inhibitors (MAOIs), and other oral diabetes medications. Tell your doctor all medications and supplements you use. It is not known whether glyburide is harmful to an unborn baby. Similar diabetes medications have caused severe hypoglycemia in newborn babies whose mothers had used the medication near the time of delivery. It is not known whether glyburide passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.

Our Micronase Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

QUESTION

______________ is another term for type 2 diabetes. See Answer
Micronase Consumer Information

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Call your doctor at once if you have:

  • dark urine, jaundice (yellowing of the skin or eyes);
  • severe skin rash, redness, or itching;
  • pale skin, easy bruising or bleeding;
  • fever, chills, sore throat, mouth sores; or
  • low levels of sodium in the body--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady.

Older adults may be more likely to have low blood sugar while taking glyburide.

Common side effects may include:

  • low blood sugar;
  • nausea, heartburn, feeling full;
  • muscle or joint pain;
  • blurred vision; or
  • mild rash or skin redness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Micronase (Glyburide)

SLIDESHOW

Type 2 Diabetes Diagnosis, Treatment, Medication See Slideshow
Micronase Professional Information

SIDE EFFECTS

Hypoglycemia

See PRECAUTIONS and OVERDOSE Sections.

Gastrointestinal Reactions

Cholestatic jaundice and hepatitis may occur rarely which may progress to liver failure; MICRONASE Tablets should be discontinued if this occurs.

Liver function abnormalities, including isolated transaminase elevations, have been reported.

Gastrointestinal disturbances, eg, nausea, epigastric fullness, and heartburn are the most common reactions, having occurred in 1.8% of treated patients during clinical trials. They tend to be dose related and may disappear when dosage is reduced.

Dermatologic Reactions

Allergic skin reactions, eg, pruritus, erythema, urticaria, and morbilliform or maculopapular eruptions occurred in 1.5% of treated patients during clinical trials. These may be transient and may disappear despite continued use of MICRONASE; if skin reactions persist, the drug should be discontinued.

Porphyria cutanea tarda and photosensitivity reactions have been reported with sulfonylureas.

Hematologic Reactions

Leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia (see PRECAUTIONS), aplastic anemia, and pancytopenia have been reported with sulfonylureas.

Metabolic Reactions

Hepatic porphyria and disulfiram-like reactions have been reported with sulfonylureas; however, hepatic porphyria has not been reported with MICRONASE and disulfiram-like reactions have been reported very rarely.

Cases of hyponatremia have been reported with glyburide and all other sulfonylureas, most often in patients who are on other medications or have medical conditions known to cause hyponatremia or increase release of antidiuretic hormone. The syndrome of inappropriate antidiuretic hormone (SIADH) secretion has been reported with certain other sulfonylureas, and it has been suggested that these sulfonylureas may augment the peripheral (antidiuretic) action of ADH and/or increase release of ADH.

Other Reactions

Changes in accommodation and/or blurred vision have been reported with glyburide and other sulfonylureas. These are thought to be related to fluctuation in glucose levels.

In addition to dermatologic reactions, allergic reactions such as angioedema, arthralgia, myalgia and vasculitis have been reported.

Read the entire FDA prescribing information for Micronase (Glyburide)

Related Resources for Micronase

Read the Micronase User Reviews »

© Micronase Patient Information is supplied by Cerner Multum, Inc. and Micronase Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

QUESTION

______________ is another term for type 2 diabetes. See Answer

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