Slideshows Images Quizzes

Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. See additional information.

Midazolam vs. Klonopin

Medical and Pharmacy Editor:

Are Midazolam and Klonopin the Same Thing?

Midazolam Injection and Syrup and Klonopin (clonazepam) are benzodiazepines used for different purposes.

Midazolam Injection is a used as a sedative before surgery or other medical procedures. Midazolam hydrochloride syrup is used in pediatric patients.

Klonopin is prescribed for the treatment of anxiety and seizure disorders.

Brand names for midazolam include Versed.

Side effects of midazolam and Klonopin that are similar include dizziness, drowsiness, headache, or trouble sleeping.

Side effects of midazolam that are different from Klonopin include nausea, vomiting, tiredness, cough, hiccups, breathing difficulties, chest congestion, agitation, slow heart rate, rash, “oversedation,” or injection site reactions (pain, swelling, redness, stiffness, blood clots, and tenderness).

Side effects of Klonopin that are different from midazolam include weakness, unsteadiness, depression, loss of orientation, problems with thinking or memory, slurred speech, dry mouth, sore gums, runny nose, loss of appetite, diarrhea, constipation, and blurred vision.

Both midazolam and Klonopin may interact with alcohol, barbiturates, or drugs that make you drowsy (narcotics, psychiatric medicines, anti-anxiety drugs, anti-seizure drugs, antihistamines, muscle relaxants, sleeping pills, or sedatives).

Midazolam may also interact with H2 blockers, theophylline, aminophylline, azole antifungals, protease inhibitors, calcium channel blockers, antibiotics, or rifampin.

Withdrawal symptoms may occur if you suddenly stop taking midazolam or Klonopin.

What Are Possible Side Effects of Midazolam?

Common side effects of Midazolam include:

  • drowsiness,
  • dizziness,
  • weakness,
  • unsteadiness,
  • depression,
  • loss of orientation,
  • headache,
  • sleep disturbances,
  • problems with thinking or memory,
  • slurred speech,
  • dry mouth,
  • sore gums,
  • runny nose,
  • loss of appetite,
  • diarrhea,
  • constipation, and
  • blurred vision.

What Are Possible Side Effects of Klonopin?

Common side effects of Klonopin include:

  • drowsiness,
  • dizziness,
  • weakness,
  • unsteadiness,
  • depression,
  • loss of orientation,
  • headache,
  • sleep disturbances,
  • problems with thinking or memory,
  • slurred speech,
  • dry mouth,
  • sore gums,
  • runny nose,
  • loss of appetite,
  • diarrhea,
  • constipation, and
  • blurred vision.

What Is Midazolam?

Midazolam HCl Injection is a benzodiazepine used as a sedative before surgery or other medical procedures.

What Is Klonopin?

Klonopin is a prescription medicine used alone or with other medicines to treat:

It is not known if Klonopin is safe or effective in treating panic disorder in children younger than 18 years old.

Klonopin is a federal controlled substance (C-IV) because it can be abused or lead to dependence.

Klonopin is a benzodiazepine medicine. Benzodiazepines can cause severe drowsiness, breathing problems (respiratory depression), coma, and death when taken with opioid medicines. Klonopin can make you sleepy or dizzy and can slow your thinking and motor skills. This may get better over time.

What Drugs Interact With Midazolam?

Midazolam may interact with H2 blockers, fluconazole, theophylline, aminophylline, erythromycin, or drugs that make you drowsy, such as: narcotics, psychiatric medicines, anti-anxiety drugs, anti-seizure drugs, antihistamines, muscle relaxants, sleeping pills, or sedatives. Tell your doctor all medications and supplements you use. During pregnancy, Midazolam should be used only if prescribed. It may harm a fetus. Infants born to mothers who have used this drug during pregnancy may have withdrawal symptoms. This drug passes into breast milk. Consult your doctor before breastfeeding. Withdrawal symptoms may occur if you suddenly stop taking this medication.

What Drugs Interact With Klonopin?

Klonopin may interact with cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, medicine for depression or anxiety, antibiotics, antifungal medicines, antidepressants, and barbiturates.

Klonopin may also interact with propantheline, MAO inhibitors, or medicines to treat psychiatric disorders.

Do not stop using Klonopin without first talking to your doctor, even if you feel fine. You may have increased seizures or unpleasant withdrawal symptoms if you stop using Klonopin suddenly.

How Should Midazolam Be Taken?

Dosing of Midazolam is individualized. The recommended premedication dose of midazolam for low risk adult patients below the age of 60 years is 0.07 to 0.08 mg/kg IM (approximately 5 mg IM) administered up to 1 hour before surgery.

How Should Klonopin Be Taken?

Klonopin topping Klonopin suddenly can cause serious problems. Stopping Klonopin suddenly can cause seizures that will not stop (status epilepticus).

Klonopin can cause abuse and dependence.

Do not stop taking Klonopin all of a sudden. Stopping Klonopin suddenly can cause seizures that do not stop, hearing or seeing things that are not there (hallucinations), shaking, and stomach and muscle cramps.

Talk to your healthcare provider about slowly stopping Klonopin to avoid withdrawal symptoms.

Physical dependence is not the same as drug addiction. Your healthcare provider can tell you more about the differences between physical dependence and drug addiction.

Take Klonopin exactly as your healthcare provider tells you. If you take Klonopin for seizures, your healthcare provider may change the dose until you are taking the right amount of medicine to control your symptoms.

Klonopin is available as a tablet.

Do not stop taking Klonopin without first talking to your healthcare provider. Stopping Klonopin suddenly can cause serious problems.

Klonopin tablets should be taken with water and swallowed whole.

If you take too much Klonopin, call your healthcare provider or local Poison Control Center right away.

Reviewed on 3/14/2019

References:
FDA. Midazolam (Versed) Prescribing Information.
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208878Orig1s000lbl.pdf
FDA. Klonopin Side Effects Drug Center.
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/017533s053,020813s009lbl.pdf

CONTINUE SCROLLING FOR RELATED SLIDESHOW

Health Solutions From Our Sponsors