Midrin Side Effects Center

Last updated on RxList: 10/1/2018
Midrin Side Effects Center

Last reviewed on RxList 10/1/2018

Midrin (isometheptene mucate, dichloralphenazone and acetaminophen) is a combination of a pain reliever and fever reducer, a sedative, and a vasoconstrictor used to treat migraine headaches or severe tension headaches. The brand name Midrin is no longer manufactured, but generic versions may be available. Common side effects of Midrin include:

  • dizziness,
  • drowsiness,
  • mood changes, and
  • nausea.

The usual adult dosage of Midrin is two capsules at once, followed by one capsule every hour until relieved, up to 5 capsules within a 12-hour period. Midrin or equivalent medications may interact with blood thinners, isoniazid, or antidepressants. Acetaminophen is contained in many combination medicines. Read all labels carefully so you don't take too much acetaminophen. Tell your doctor all medications you are taking. During pregnancy, this medication should be used only when prescribed. Discuss the risks and benefits with your doctor. This medication passes into breast milk. Consult your doctor before breastfeeding.

Our Midrin (isometheptene mucate, dichloralphenazone and acetaminophen) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Who suffers more frequently from migraine headaches? See Answer
Midrin Professional Information


Transient dizziness and skin rash may appear in hypersensitive patients. This can usually be eliminated by reducing the dose.

Read the entire FDA prescribing information for Midrin (Acetaminophen, Isometheptene and Dichloralphenazone)


16 Surprising Headache Triggers and Tips for Pain Relief See Slideshow

© Midrin Patient Information is supplied by Cerner Multum, Inc. and Midrin Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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