Medical Editor: John P. Cunha, DO, FACOEP
Midrin (isometheptene mucate, dichloralphenazone and acetaminophen) is a combination of a pain reliever and fever reducer, a sedative, and a vasoconstrictor used to treat migraine headaches or severe tension headaches. The brand name Midrin is no longer manufactured, but generic versions may be available. Common side effects of Midrin include:
- mood changes, and
The usual adult dosage of Midrin is two capsules at once, followed by one capsule every hour until relieved, up to 5 capsules within a 12-hour period. Midrin or equivalent medications may interact with blood thinners, isoniazid, or antidepressants. Acetaminophen is contained in many combination medicines. Read all labels carefully so you don't take too much acetaminophen. Tell your doctor all medications you are taking. During pregnancy, this medication should be used only when prescribed. Discuss the risks and benefits with your doctor. This medication passes into breast milk. Consult your doctor before breastfeeding.
Our Midrin (isometheptene mucate, dichloralphenazone and acetaminophen) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Dizziness, drowsiness, or nausea may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Midrin (Acetaminophen, Isometheptene and Dichloralphenazone)
Transient dizziness and skin rash may appear in hypersensitive patients. This can usually be eliminated by reducing the dose.
Read the entire FDA prescribing information for Midrin (Acetaminophen, Isometheptene and Dichloralphenazone)