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Prescription Migraine Medications (cont.)

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Which medications are used for preventing migraines?

Preventative therapy should be considered for patients who suffer from recurrent migraines that cause significant disability, frequent migraines that require treatment more than twice a week, or migraines that do not respond or respond poorly to symptomatic treatments. Currently there are no drugs that specifically target and prevent migraines. Certain blood pressure medications as well as some antidepressants, anti-seizure drugs, and herbals have been shown to have beneficial effects in preventing migraine headaches. It's important to understand that prophylactic medicines may not produce any significant benefits right away and maximal effects may not be seen for weeks to up to 6 months.

Although a number of medications have been used for the prevention of migraines, the medications that have been shown to be effective in controlled clinical trials, and are therefore recommended by the American Headache Society and the American Academy of Neurology (AAN) migraine prevention guidelines include:

Other medications that are used to prevent migraine headaches include:

ACE Inhibitors

Angiotensin II Receptor Antagonists (ARBS)


Calcium Channel Blockers

Tricyclic Antidepressants

Other Antidepressants

Antiseizure Medications


Medically Reviewed by a Doctor on 4/27/2016

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