Last updated on RxList: 6/27/2018
Minirin Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 6/27/2018

Minirin (desmopressin acetate nasal spray) is a vasopressin analog indicated as antidiuretic replacement therapy in the management of central diabetes insipidus for adults and pediatric patients 4 years of age and older. Minirin is available in generic form. Common side effects of Minirin include:

The adult dose of Minirin is 10 mcg to 40 mcg daily (either as a single dose or divided into two or three daily doses. The pediatric dose of Minirin is 10 mcg once daily into one nostril up to 30 mcg once daily (or 30 mcg divided as 20 mcg during the morning and 10 mcg at night. Minirin may interact with tricyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs), chlorpromazine, opiate analgesics, nonsteroidal anti-inflammatory drugs (NSAIDs), lamotrigine, oxybutynin, carbamazepine, and other vasoconstrictors. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Minirin. Minirin passes into breast milk in negligible amounts and is not expected to have an affect on a breastfeeding infant. Consult your doctor before breastfeeding.

Our Minirin (desmopressin acetate nasal spray) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Minirin Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • signs of low sodium--headache, confusion, hallucinations, muscle pain or weakness, drowsiness, vomiting, loss of appetite, and feeling restless or irritable;
  • rapid weight gain, swelling in your feet or ankles;
  • a seizure (convulsions); or
  • nasal problems--runny or stuffy nose, sinus congestion.

Low sodium may be more likely to occur in children and older adults.

Common side effects may include:

  • stuffy nose, runny nose, sinus pain, sneezing, nosebleeds, discomfort in your nose;
  • sore throat, cough;
  • dizziness;
  • increased blood pressure;
  • nausea, stomach cramps;
  • headache, back pain; or
  • flushing (warmth, redness, or tingly feeling).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Minirin (Desmopressin Acetate Nasal Spray)

Minirin Professional Information


The following serious reactions are described below and elsewhere in the labeling:

  • Hyponatremia [see WARNINGS AND PRECAUTIONS].
  • Altered Absorption in Patients with Changes in Nasal Mucosa [see WARNINGS AND PRECAUTIONS].

The following adverse reactions have been identified during post-approval use of desmopressin acetate. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure:

Increase in blood pressure, headache, nasal congestion, rhinitis, nosebleed, sore throat, cough, upper respiratory infections, nausea, flushing, and abdominal cramps.

Water intoxication with hyponatremia

Hyponatremic convulsions associated with concomitant use of the following medications: oxybutinin and imipramine [see DRUG INTERACTIONS].

Severe allergic reactions and anaphylaxis [see CONTRAINDICATIONS]

Read the entire FDA prescribing information for Minirin (Desmopressin Acetate Nasal Spray)

© Minirin Patient Information is supplied by Cerner Multum, Inc. and Minirin Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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