Minitran Side Effects Center

Last updated on RxList: 9/15/2022
Minitran Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Minitran?

Minitran (nitroglycerin) is an organic nitrate indicated for the prevention of chest pain (angina pectoris) due to coronary artery disease. The onset of action of transdermal nitroglycerin is not sufficiently rapid for this product to be useful in aborting an acute attack. The brand name Minitran has been discontinued. It may be available as a generic.

What Are Side Effects of Minitran?

Common side effects of Minitran include:

Minitran may cause serious side effects including:

  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • sudden vision loss,
  • blurred vision,
  • tunnel vision,
  • eye pain or swelling,
  • seeing halos around lights,
  • fast, irregular, or pounding heartbeats,
  • fluttering in your chest,
  • shortness of breath,
  • sudden dizziness,
  • lightheadedness,
  • fainting,
  • severe headache,
  • confusion,
  • slurred speech,
  • arm or leg weakness,
  • trouble walking,
  • loss of coordination,
  • feeling unsteady,
  • very stiff muscles,
  • high fever,
  • profuse sweating, and
  • tremors

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Minitran

The suggested starting dose of Minitran is between 0.2 mg/hour and 0.4 mg/hour.

What Drugs, Substances, or Supplements Interact with Minitran?

Minitran may interact with alcohol, other vasodilators, phosphodiesterase inhibitors, and riociguat. Tell your doctor all medications and supplements you use.

Minitran During Pregnancy or Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using Minitran; it is unknown how it would affect a fetus. It is unknown if Minitran passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Minitran (nitroglycerin) Transdermal Delivery System Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Minitran Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • worsening chest pain;
  • pounding heartbeats or fluttering in your chest;
  • slow heart rate;
  • a light-headed feeling, like you might pass out; or
  • heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating.

Serious side effects may be more likely in older adults.

Nitroglycerin can cause severe headaches. These headaches may gradually become less severe as you continue to use nitroglycerin. Do not stop using this medicine. Ask your doctor before using any headache pain medication.

Common side effects may include:

  • headache; or
  • feeling light-headed.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Minitran (Nitroglycerin Transdermal Delivery System)

SLIDESHOW

Heart Disease: Symptoms, Signs, and Causes See Slideshow
Minitran Professional Information

SIDE EFFECTS

Adverse reactions to nitroglycerin are generally dose related, and almost all of these reactions are the result of nitroglycerin’s activity as a vasodilator. Headache, which may be severe, is the most commonly reported side effect. Headache may be recurrent with each daily dose, especially at higher doses. Transient episodes of lightheadedness, occasionally related to blood pressure changes, may also occur. Hypotension occurs infrequently, but in some patients it may be severe enough to warrant discontinuation of therapy. Syncope, crescendo angina, and rebound hypertension have been reported but are uncommon.

Allergic reactions to nitroglycerin are also uncommon, and the great majority of those reported have been cases of contact dermatitis or fixed drug eruptions in patients receiving nitroglycerin in ointments or patches. There have been a few reports of genuine anaphylactoid reactions, and these reactions can probably occur in patients receiving nitroglycerin by any route.

Extremely rarely, ordinary doses of organic nitrates have caused methemoglobinemia in normal-seeming patients. Methemoglobinemia is so infrequent at these doses that further discussion of its diagnosis and treatment is deferred (see OVERDOSE).

Application-site irritation may occur but is rarely severe.

In two placebo-controlled trials of intermittent therapy with nitroglycerin patches at 0.2 to 0.8 mg/hr, the most frequent adverse reactions among 307 subjects were as follows:

  Placebo Patch
Headache 18% 63%
Lightheadedness 4% 6%
Hypotension and/or syncope 0% 4%
Increased angina 2% 2%

To report SUSPECTED ADVERSE REACTIONS, contact Valeant Pharmaceuticals North America LLC at 1-800-321-4576 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Read the entire FDA prescribing information for Minitran (Nitroglycerin Transdermal Delivery System)

QUESTION

In the U.S., 1 in every 4 deaths is caused by heart disease. See Answer

© Minitran Patient Information is supplied by Cerner Multum, Inc. and Minitran Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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