Last updated on RxList: 8/27/2020
Mitigare Side Effects Center

What Is Mitigare?

Mitigare (colchicine) is an alkaloid used to prevent gout flares in adults.

What Are Side Effects of Mitigare?

Common side effects of Mitigare include: gastrointestinal symptoms, such as:

  • diarrhea
  • nausea
  • vomiting
  • abdominal pain, and
  • cramping

Dosage for Mitigare

For prophylaxis of gout flares, the recommended dosage of Mitigare is 0.6 mg once or twice daily. The maximum dose is 1.2 mg per day.

What Drugs, Substances, or Supplements Interact with Mitigare?

Mitigare may interact with clarithromycin, ketoconazole, grapefruit juice, erythromycin, verapamil, cyclosporine, HMG-CoA reductase inhibitors, and fibrates. Tell your doctor all medications and supplements you use.

Mitigare During Pregnancy and Breastfeeding

During pregnancy, Mitigare should be taken only if prescribed. This drug passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Mitigare (colchicine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Gout is a form of arthritis. See Answer
Mitigare Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • muscle pain or weakness;
  • numbness or tingly feeling in your fingers or toes;
  • pale or gray appearance of your lips, tongue, or hands;
  • severe or ongoing vomiting or diarrhea;
  • fever, chills, body aches, flu symptoms; or
  • easy bruising, unusual bleeding, feeling weak or tired.

Common side effects may include:

  • nausea, vomiting, stomach pain; or
  • diarrhea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Mitigare (Colchicine Capsules)


Gout Attack Symptoms, Causes, Treatment, and Diet See Slideshow
Mitigare Professional Information


Gastrointestinal disorders are the most common adverse reactions with colchicine. They are often the first signs of toxicity and may indicate that the colchicine dose needs to be reduced or therapy stopped. These include diarrhea, nausea, vomiting, and abdominal pain.

Colchicine has been reported to cause neuromuscular toxicity, which may present as muscle pain or weakness [see WARNINGS AND PRECAUTIONS].

Toxic manifestations associated with colchicine include myelosuppression, disseminated intravascular coagulation, and injury to cells in the renal, hepatic, circulatory, and central nervous system. These most often occur with excessive accumulation or overdosage [see OVERDOSE].

The following reactions have been reported with colchicine. These have been generally reversible by interrupting treatment or lowering the dose of colchicine:

Digestive: abdominal cramping, abdominal pain, diarrhea, lactose intolerance, nausea, vomiting

Neurological: sensory motor neuropathy

Dermatological: alopecia, maculopapular rash, purpura, rash

Hematological: leukopenia, granulocytopenia, thrombocytopenia, pancytopenia, aplastic anemia

Hepatobiliary: elevated AST, elevated ALT

Musculoskeletal: myopathy, elevated CPK, myotonia, muscle weakness, muscle pain, rhabdomyolysis

Reproductive: azoospermia, oligospermia

To report SUSPECTED ADVERSE REACTIONS, contact Hikma Americas, Inc. at 1-800-962-8364 or FDA at 1-800-FDA-1088 or

Read the entire FDA prescribing information for Mitigare (Colchicine Capsules)

© Mitigare Patient Information is supplied by Cerner Multum, Inc. and Mitigare Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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