Reviewed on 4/22/2022

What Is Mitomycin and How Does It Work?

Mitomycin is a prescription medication used in combination with other anti-cancer drugs to treat stomach and pancreas cancer.

  • Mitomycin is available under the following different brand names: Mitomycin C, Mutamycin

What Are Dosages of Mitomycin?

Adult dosage

Powder for injection

  • 5mg
  • 20mg
  • 40mg

Stomach Cancer, Pancreas Cancer

Adult dosage

  • 20 mg/m² IV every 6-8 Weeks 

Dosage Considerations – Should be Given as Follows: 

  • See “Dosages”

What Are Side Effects Associated with Using Mitomycin?

Common side effects of Mitomycin include:

  • fever or other signs of infection,
  • nausea, 
  • vomiting, 
  • diarrhea, 
  • loss of appetite,
  • mouth sores,
  • drowsiness, 
  • headache,
  • blurred vision, and 
  • temporary hair loss.

Serious side effects of Mitomycin include:

  • signs of infection: fever, weakness, cold or flu symptoms, skin sores, frequent or recurring illness,
  • wheezing
  • chest tightness, 
  • new or worsening cough, 
  • trouble breathing,
  • blisters or ulcers in the mouth, 
  • red or swollen gums, 
  • trouble swallowing,
  • pain, burning, redness, swelling, irritation, or skin changes at the injection site,
  • unusual bruising or bleeding, 
  • pale skin, 
  • confusion, 
  • tiredness or irritability, 
  • stomach pain, 
  • bloody diarrhea, 
  • red or pink urine, 
  • swelling, rapid weight gain, and 
  • little or no urination.

Rare side effects of Mitomycin include:

  • none 
This is not a complete list of side effects and other serious side effects or health problems that may occur as a result of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.


Skin Cancer Symptoms, Types, Images See Slideshow

What Other Drugs Interact with Mitomycin?

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

  • Mitomycin has severe interactions with no other drugs.
  • Mitomycin has serious interactions with the following drugs:
    • bacitracin
    • deferiprone
    • erdafitinib
    • lasmiditan
    • palifermin
    • ropeginterferon alfa 2b
    • sotorasib
    • tepotinib
    • voxelotor
  • Mitomycin has moderate interactions with at least 33 other drugs.
  • Mitomycin has minor interactions with no other drugs. 

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all the products you use. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions or concerns.

What Are Warnings and Precautions for Mitomycin?


Effects of drug abuse

  • None

Short-Term Effects

  • See “What Are Side Effects Associated with Using Mitomycin?”

Long-Term Effects

  • See “What Are Side Effects Associated with Using Mitomycin?”


Pregnancy and Lactation

  • Use in LIFE-THREATENING emergencies when no safer drug is available. Positive evidence of human fetal risk.
  • Lactation
    • Not known if excreted in breast milk, do not nurse
Medscape. Mitomycin.

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