How Do Anti-Asthmatic Monoclonal Antibodies Work?

Reviewed on 10/7/2021

How do anti-asthmatic monoclonal antibodies work?

Anti-asthmatic monoclonal antibodies are medications that are used to treat severe asthma and other inflammatory conditions that do not adequately respond to standard anti-inflammatory treatments such as corticosteroids.

Anti-asthmatic monoclonal antibodies are laboratory-produced proteins cloned from a single type of white cell. Anti-asthmatic monoclonal antibodies block the activity of specific types of inflammatory proteins (cytokines) released by immune cells that are implicated in chronic pulmonary inflammatory diseases.

Most anti-asthmatic monoclonal antibodies work by blocking the activity of interleukin-5 (IL-5), a cytokine secreted by many types of cells. IL-5 is responsible for the maturation, release and survival of eosinophils, an immune cell that plays a prominent role in allergic airway diseases.

Interleukin-5 also stimulates the release of cytokines from basophils, another type of immune cells involved in airway inflammation. Interleukin-5 activates eosinophils and basophils by binding to protein molecules on their surfaces known as IL-5 receptors which respond to IL-5 and initiate inflammation.

Anti-asthmatic monoclonal antibodies bind to IL-5 receptors on eosinophils and basophils and prevent interleukin-5 from activating them. Anti-IL-5 monoclonal antibodies reduce inflammation in the following ways:

Some anti-asthmatic monoclonal antibodies block the activity of immunoglobulin E (IgE), another type of antibody that the immune system produces in response to allergens. The anti-IgE monoclonal antibodies bind to IgE and prevent the stimulation of IgE receptors on mast cells and basophils, and the resultant release of cytokines.

A new anti-asthmatic monoclonal antibody that is in clinical trials, prevents inflammation by inhibiting thymic stromal lymphopoietin (TSLP). TSLP is a cytokine that triggers airway inflammation, and is produced by epithelial cells in the lining of the respiratory system.


Asthma is a chronic respiratory disease. See Answer

How are anti-asthmatic monoclonal antibodies used?

Anti-asthmatic monoclonal antibodies are administered as intravenous or subcutaneous injections for the treatment of the following conditions:


Orphan designation:

What are side effects of anti-asthmatic monoclonal antibodies?

Side effects of anti-asthmatic monoclonal antibodies may include the following:

Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.


What Is Asthma? Symptoms, Causes, and Treatments See Slideshow

What are names of anti-asthmatic monoclonal antibody drugs?

Generic and brand names of anti-asthmatic monoclonal antibody drugs include:


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