Monodox Side Effects Center

Last updated on RxList: 2/24/2022
Monodox Side Effects Center

What Is Monodox?

Monodox (doxycycline monohydrate) is a tetracycline antibiotic used to treat many different bacterial infections, such as urinary tract infections, acne, gonorrhea, and chlamydia, periodontitis (gum disease), and others. Monodox is also used to treat blemishes, bumps, and acne-like lesions caused by rosacea (but will not treat facial redness caused by rosacea). Monodox is available in generic form.

What Are Side Effects of Monodox?

Common side effects of Monodox include:

Tell your doctor if you have serious side effects of Monodox including:

  • sunburn (sun sensitivity),
  • painful or difficult swallowing, or
  • changes in the amount of urine.

Dosage for Monodox

The usual adult dose of Monodox is 200 mg on the first day of treatment (100 mg every 12 hours or 50 mg every 6 hours), and a maintenance dose of 100 mg/day. The maintenance dose may be taken as a single dose or as 50 mg every 12 hours. The recommended dosage for pediatric patients weighing 100 pounds or less is 2 mg/lb of body weight divided into two doses on the first day of treatment, followed by 1 mg/lb of body weight given as a single daily dose or divided into two doses, on subsequent days.

What Drugs, Substances, or Supplements Interact with Monodox?

Monodox may interact with cholesterol-lowering medications, isotretinoin, tretinoin, antacids, bismuth subsalicylate (e.g., Pepto-Bismol), blood thinners, penicillin antibiotics, or minerals such as iron, zinc, calcium, magnesium, and over-the-counter vitamin supplements. Tell your doctor all medications and supplements you are taking.

Monodox During Pregnancy or Breastfeeding

Monodox is not recommended for use during pregnancy. It may harm a fetus. Use reliable forms of birth control while taking this medication. This drug passes into breast milk but is unlikely to harm a nursing infant. Consult your doctor before breastfeeding.

Additional Information

Our Monodox (doxycycline monohydrate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Monodox Consumer Information

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Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. This reaction may occur several weeks after you began using doxycycline.

Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody;
  • throat irritation, trouble swallowing;
  • chest pain, irregular heart rhythm, feeling short of breath;
  • little or no urination;
  • low white blood cell counts--fever, chills, swollen glands, body aches, weakness, pale skin, easy bruising or bleeding;
  • increased pressure inside the skull--severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes; or
  • signs of liver or pancreas problems--loss of appetite, upper stomach pain (that may spread to your back), tiredness, nausea or vomiting, fast heart rate, dark urine, jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • nausea, vomiting, upset stomach, loss of appetite;
  • mild diarrhea;
  • skin rash or itching;
  • darkened skin color; or
  • vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Monodox Professional Information

SIDE EFFECTS

Due to oral doxycycline's virtually complete absorption, side effects to the lower bowel, particularly diarrhea, have been infrequent. The following adverse reactions have been observed in patients receiving tetracyclines.

Gastrointestinal

Anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis, and inflammatory lesions (with monilial overgrowth) in the anogenital region, and pancreatitis. Hepatotoxicity has been reported. These reactions have been caused by both the oral and parenteral administration of tetracyclines. Rare instances of esophagitis and esophageal ulcerations have been reported in patients receiving capsule and tablet forms of drugs in the tetracycline class. Most of these patients took medications immediately before going to bed (see DOSAGE AND ADMINISTRATION).

Skin

Maculopapular and erythematous rashes, Stevens-Johnson syndrome, toxic epidermal necrolysis, and erythema multiforme have been reported. Exfoliative dermatitis has been reported but is uncommon. Photosensitivity is discussed above (see WARNINGS).

Renal Toxicity

Rise in BUN has been reported and is apparently dose related (see WARNINGS).

Hypersensitivity Reactions

Urticaria, angioneurotic edema, anaphylaxis, anaphylactoid purpura, serum sickness, pericarditis, and exacerbation of systemic lupus erythematosus.

Blood

Hemolytic anemia, thrombocytopenia, neutropenia, and eosinophilia have been reported with tetracyclines.

Other

Intracranial hypertension (IH, pseudotumor cerebri) has been associated with the use of tetracyclines (see PRECAUTIONS-General).

When given over prolonged periods, tetracyclines have been reported to produce brown-black microscopic discoloration of the thyroid gland. No abnormalities of thyroid function are known to occur.

DRUG INTERACTIONS

Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage.

Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracyclines in conjunction with penicillin.

Absorption of tetracyclines is impaired by antacids containing aluminum, calcium, or magnesium, and iron-containing preparations.

Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline.

The concurrent use of tetracycline and methoxyflurane has been reported to result in fatal renal toxicity.

Concurrent use of tetracycline may render oral contraceptives less effective.

Drug/Laboratory Test Interactions

False elevations of urinary catecholamine levels may occur due to interference with the fluorescence test.

Read the entire FDA prescribing information for Monodox (Doxycycline)

© Monodox Patient Information is supplied by Cerner Multum, Inc. and Monodox Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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