Morning glory syndrome: A birth defect of the optic nerve (the nerve to the eye) in which there is a coloboma (cleft) of the optic disc. The coloboma results in a funnel-shaped optic nerve head with a white dot in the center, an elevated ring of pigment around the disk, and vessels radiating out from the ring like spokes. Reflection from within the eye may give the appearance of a white pupil. Vision in the affected eye is severely impaired. There is an increased risk of retinal detachment. Also called morning glory anomaly.