Morphine Sulfate Tablets

Last reviewed on RxList: 7/14/2020
Morphine Sulfate Tablets Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Morphine?

Morphine sulfate extended-release tablets are an opioid agonist product indicated for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate. Morphine sulfate extended-release tablets are available in generic form.

What Are Side Effects of Morphine?

Common side effects of morphine sulfate extended-release tablets include:

  • constipation,
  • nausea,
  • drowsiness,
  • dizziness,
  • vomiting,
  • sweating,
  • feeling uneasy, and
  • euphoric mood.

Dosage for Morphine

For opioid-naïve and opioid non-tolerant patients, the initial dose of morphine sulfate extended-release is 15 mg tablets orally every 8 to 12 hours.

What Drugs, Substances, or Supplements Interact with Morphine?

Morphine sulfate extended-release tablets may interact with other central nervous system (CNS) depressants (such as sedatives, anxiolytics, hypnotics, tranquilizers, general anesthetics, phenothiazines, neuroleptics, other opioids, and alcohol), pentazocine, nalbuphine, butorphanol, buprenorphine, skeletal muscle relaxants, monoamine oxidase inhibitors (MAOIs), cimetidine, diuretics, antocholinergics, and PGP-inhibitors (e.g., quinidine). Tell your doctor all medications and supplements you use.

Morphine During Pregnancy and Breastfeeding

Morphine sulfate is not recommended for use during pregnancy; it may harm a fetus. Prolonged use of morphine sulfate during pregnancy can result in withdrawal signs in newborns. Morphine sulfate passes into breast milk and may cause adverse effects on a nursing infant. Breastfeeding while using morphine sulfate is not recommended. Withdrawal symptoms may occur if you suddenly stop taking morphine sulfate.

Additional Information

Our Morphine Sulfate Tablets Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

QUESTION

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Morphine Sulfate Tablets Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

Call your doctor at once if you have:

  • slow heart rate, sighing, weak or shallow breathing, breathing that stops;
  • chest pain, fast or pounding heartbeats;
  • extreme drowsiness, feeling like you might pass out;
  • serotonin syndrome--agitation, hallucinations, fever, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, diarrhea; or
  • low cortisol levels--nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.

Serious breathing problems may be more likely in older adults and people who are debilitated or have wasting syndrome or chronic breathing disorders.

Common side effects may include:

  • drowsiness, dizziness, tiredness;
  • constipation, stomach pain, nausea, vomiting;
  • sweating; or
  • feelings of extreme happiness or sadness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Morphine Sulfate Tablets (morphone sulfate)

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Morphine Sulfate Tablets Professional Information

SIDE EFFECTS

The following serious adverse reactions are described elsewhere in the labeling:

Clinical Trial Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

Morphine sulfate extended-release tablets may increase the risk of serious adverse reactions such as those observed with other opioid analgesics, including respiratory depression, apnea, respiratory arrest, circulatory depression, hypotension, or shock [see OVERDOSE].

Most Frequently Observed Reactions

In clinical trials, the most common adverse reactions with morphine sulfate extended-release tablets were constipation, dizziness, sedation, nausea, vomiting, sweating, dysphoria, and euphoric mood.

Some of these effects seem to be more prominent in ambulatory patients and in those not experiencing severe pain.

Less Frequently Observed Reactions

Cardiovascular disorders: tachycardia, bradycardia, palpitations

Eye disorders: visual impairment, vision blurred, diplopia, miosis

Gastrointestinal disorders: dry mouth, diarrhea, abdominal pain, constipation, dyspepsia

General disorders and administration site conditions: chills, feeling abnormal, edema, edema peripheral, weakness

Hepatobiliary disorders: biliary colic

Metabolism and nutrition disorders: anorexia

Musculoskeletal and connective tissue disorders: muscle rigidity, muscle twitching

Nervous system disorders: presyncope, syncope, headache, tremor, uncoordinated muscle movements, convulsion, intracranial pressure increased, taste alteration, paresthesia, nystagmus

Psychiatric disorders: agitation, mood altered, anxiety, depression, abnormal dreams, hallucination, disorientation, insomnia

Renal and urinary disorders: urinary retention, urinary hesitation, antidiuretic effects

Reproductive system and breast disorders: reduced libido and/or potency

Respiratory, thoracic and mediastinal disorders: laryngospasm

Skin and subcutaneous tissue disorders: pruritus, urticaria, rash

Vascular disorders: flushing, hypotension, hypertension

Post-Marketing Experience

The following adverse reactions have been identified during postapproval use of morphine sulfate extended-release tablets: amenorrhea, asthenia, bronchospasm, confusional state, drug hypersensitivity, fatigue, hyperalgesia, hypertonia, ileus, increased hepatic enzymes, intestinal obstruction, lethargy, malaise, pulmonary edema, thinking disturbances, somnolence, and vertigo.

Anaphylaxis has been reported with ingredients contained in morphine sulfate extended-release tablets. Advise patients how to recognize such a reaction and when to seek medical attention.

Read the entire FDA prescribing information for Morphine Sulfate Tablets (morphone sulfate)

© Morphine Sulfate Tablets Patient Information is supplied by Cerner Multum, Inc. and Morphine Sulfate Tablets Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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