Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 5/16/2022

What is Motofen and how is it used?

Motofen (difenoxin and atropine sulfate) is a prescription medicine used to treat the symptoms of Diarrhea. Motofen may be used alone or with other medications.

Motofen belongs to a class of drugs called Antidiarrheals.

It is not known if Motofen is safe and effective in children.

What are the possible side effects of Motofen?

Motofen may cause serious side effects including:

  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • stomach pain or swelling,
  • severe nausea,
  • vomiting,
  • mental or mood changes,
  • confusion,
  • depression,
  • restlessness,
  • numbness or tingling in the arms or legs,
  • eye pain,
  • swelling or redness of the eye,
  • vision changes,
  • blurred vision,
  • seeing halos around lights,
  • rash,
  • itching, and
  • severe dizziness

Get medical help right away, if you have any of the symptoms listed above.

The most common side effects of Motofen include:

  • drowsiness,
  • dizziness,
  • headache,
  • tiredness,
  • blurred vision,
  • dry mouth, and
  • loss of appetite

Tell the doctor if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Motofen. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Each five-sided dye free MOTOFEN® tablet contains: 1 mg of difenoxin (equivalent to 1.09 mg of difenoxin hydrochloride) and 0.025 mg of atropine sulfate (equivalent to 0.01 mg of atropine).

Difenoxin hydrochloride, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-4-piperidinecarboxylic acid monohydrochloride, is an orally administered antidiarrheal agent which is chemically related to the narcotic meperidine. The structural formula is:

Difenoxin hydrochloride - Structural Formula Illustration

Atropine sulfate is present to discourage deliberate overdose.

Atropine sulfate, an anticholinergic, is benzeneacetic acid, α-(hydroxymethyl)-, 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, endo-(±)-, (2:1) (salt), monohydrate and has the following structural formula:

Atropine sulfate - Structural Formula Illustration

Inactive Ingredients: calcium stearate, cellulose, lactose, corn starch.