Mupirocin Cream

Last updated on RxList: 6/29/2021
Mupirocin Cream Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Mupirocin Cream?

Mupirocin cream is an RNA synthetase inhibitor antibacterial indicated for the treatment of secondarily infected traumatic skin lesions (up to 10 cm in length or 100 cm2 in area) due to susceptible isolates of Staphylococcus aureus and Streptococcus pyogenes. Mupirocin cream is available in generic form.

What Are Side Effects of Mupirocin Cream?

Common side effects of mupirocin cream include:

  • headache,
  • rash,
  • nausea,
  • abdominal pain,
  • burning at application site,
  • severe bacterial skin infection (cellulitis),
  • skin inflammation or rash,
  • dizziness,
  • itching,
  • secondary wound infection, and
  • mouth sores.

Tell your doctor if you have serious side effects of mupirocin cream including:

  • severe allergic reactions (hives, trouble breathing, wheezing, swelling of your face/lips/mouth/tongue, dizziness, fast heartbeat or pounding in your chest, rash over your whole body),
  • eye irritation,
  • irritation in the area mupirocin cream is used, or
  • a type of diarrhea called clostridium difficile-associated diarrhea (CDAD).

Dosage for Mupirocin Cream

Apply a small amount of mupirocin cream, with a cotton swab or gauze pad, to the affected are a 3 times daily for 10 days.

What Drugs, Substances, or Supplements Interact with Mupirocin Cream?

Mupirocin cream may interact with other drugs. Tell your doctor all medications and supplements you use.

Mupirocin Cream During Pregnancy or Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using mupirocin cream; it is unknown how it may affect a fetus. It is unknown if mupirocin cream passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Mupirocin Cream Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Mupirocin Cream Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; dizziness, fast or pounding heartbeats; wheezing, difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody;
  • severe itching, rash, or other irritation of treated skin;
  • unusual skin blistering or peeling; or
  • any signs of a new skin infection.

Common side effects may include:

  • burning, stinging;
  • itching; or
  • pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Mupirocin Cream (mupirocin cream)


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Mupirocin Cream Professional Information


The following adverse reactions are discussed in more detail in other sections of the labeling:

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice.

In 2 randomized, double-blind, double-dummy trials, 339 subjects were treated with topical mupirocin cream plus oral placebo. Adverse reactions occurred in 28 (8.3%) subjects. The following adverse reactions were reported by at least 1% of subjects in connection with the use of mupirocin cream in clinical trials: headache (1.7%), rash (1.1%), and nausea (1.1%).

Other adverse reactions which occurred in less than 1% of subjects were: abdominal pain, burning at application site, cellulitis, dermatitis, dizziness, pruritus, secondary wound infection, and ulcerative stomatitis.

In a supportive trial in the treatment of secondarily infected eczema, 82 subjects were treated with mupirocin cream. The incidence of adverse reactions was as follows: nausea (4.9%), headache and burning at application site (3.6% each), pruritus (2.4%), and 1 report each of abdominal pain, bleeding secondary to eczema, pain secondary to eczema, hives, dry skin, and rash.

Postmarketing Experience

In addition to adverse reactions reported from clinical trials, the following reactions have been identified during postmarketing use of mupirocin cream. Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. These reactions have been chosen for inclusion due to a combination of their seriousness, frequency of reporting, or potential causal relationship to mupirocin cream.

Immune System Disorders

Systemic allergic reactions, including anaphylaxis, urticaria, angioedema, and generalized rash [see WARNINGS AND PRECAUTIONS].

Read the entire FDA prescribing information for Mupirocin Cream (mupirocin cream)

© Mupirocin Cream Patient Information is supplied by Cerner Multum, Inc. and Mupirocin Cream Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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