Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 6/5/2023

Drug Summary

What Is Mycostatin?

Mycostatin (nystatin) Cream or Powder is a topical (for the skin) antifungal used to treat fungal skin infections. Mycostatin Cream or Powder is available in generic form.

What Are Side Effects of Mycostatin?

Side effects of Mycostatin Cream or Powder are uncommon but may include:

  • skin irritation or redness,
  • nausea,
  • stomach upset,
  • vomiting, or
  • diarrhea.

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheadedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Mycostatin

The adult and pediatric dose of Mycostatin cream is to apply liberally to affected areas twice daily or as indicated until healing is complete. The adult and pediatric dose of Mycostatin powder for candidal lesions is to apply two or three times daily until healing is complete. For fungal infection of the feet caused by Candida species, the powder should be dusted on the feet and in all foot wear.

What Drugs, Substances, or Supplements Interact with Mycostatin?

There may be other drugs that can interact with Mycostatin. Tell your healthcare provider about all your prescription and over-the-counter medications and supplements you use. Do not start a new medication without telling your healthcare provider.

Mycostatin During Pregnancy or Breastfeeding

Mycostatin should be used only if prescribed during pregnancy. It is not known whether this drug passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Mycostatin (nystatin) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

Drug Description


Nystatin is a polyene antifungal antibiotic obtained from Streptomyces nursei.

Structural formula:

MYCOSTATIN (nystatin) Structural Formula Illustration

Mycostatin® Cream (Nystatin Cream) and Mycostatin® Topical Powder (Nystatin Topical Powder) are for dermatologic use.

MYCOSTATIN® (Nystatin) Cream for topical use, contains 100,000 USP nystatin units per gram. Inactive ingredients: aluminum hydroxide concentrated wet gel, titanium dioxide, propylene glycol, cetearyl alcohol (and) ceteareth-20, white petrolatum, sorbitol solution, glyceryl monostearate, polyethylene glycol monostearate, sorbic acid and simethicone.

MYCOSTATIN® (Nystatin) Topical Powder contains 100,000 USP nystatin units per gram dispersed in talc.

Indications & Dosage


Nystatin topical preparations are indicated in the treatment of cutaneous or mucocutaneous mycotic infections caused by Candida albicans and other susceptible Candida species.

These preparations are not indicated for systemic, oral, intravaginal or ophthalmic use.


Very moist lesions are best treated with the topical dusting powder.

MYCOSTATIN (nystatin) ® Cream

Adults and Pediatric Patients (Neonates and Older): Apply liberally to affected areas twice daily or as indicated until healing is complete.

MYCOSTATIN (nystatin) ® Topical Powder

Adults and Pediatric Patients (Neonates and Older): Apply to candidal lesions two or three times daily until healing is complete. For fungal infection of the feet caused by Candida species, the powder should be dusted on the feet, as well as, in all foot wear.


MYCOSTATIN® Cream: 100,000 units nystatin per gram in an aqueous, perfumed vanishing cream base, in 30 g (NDC 0003-0579-31) tubes.

MYCOSTATIN® Topical Powder: 100,000 units nystatin per gram in 15 g (NDC 0003-0593-20) plastic squeeze bottles.


MYCOSTATIN® (Nystatin) is also available as vaginal tablets and in oral formulations (pastilles, suspension, tablets). See package inserts for complete prescribing information.


MYCOSTATIN (nystatin) ® Cream: Store at room temperature, avoid freezing.

MYCOSTATIN (nystatin) ® Topical Powder: Store at room temperature, avoid excessive heat (40° C/104° F). Keep tightly closed.

Westwood-Squibb Pharmaceuticals, Inc., A Bristol-Myers Squibb Company, Princeton, NJ 08543 USA.

Side Effects & Drug Interactions


The frequency of adverse events reported in patients using Mycostatin (nystatin) ® preparations is less than 0.1%. The more common events that were reported include allergic reactions, burning, itching, rash, eczema, and pain on application. (See PRECAUTIONS: General.)


No information provided.

Warnings & Precautions


No information provided.



Nystatin, topical preparations should not be used for the treatment of systemic, oral, intravaginal or ophthalmic infections.

If irritation or sensitization develops, treatment should be discontinued and appropriate measures taken as indicated. It is recommended that KOH smears, cultures, or other diagnostic methods be used to confirm the diagnosis of cutaneous or mucocutaneous candidiasis and to rule out infection caused by other pathogens.

Laboratory Tests

If there is a lack of therapeutic response, KOH smears, cultures, or other diagnostic methods should be repeated.

Carcinogenesis, Mutagenesis, Impairment of Fertility

No long-term animal studies have been performed to evaluate the carcinogenic potential of nystatin. No studies have been performed to determine the mutagenicity of nystatin or its effects on male or female fertility.

Pregnancy: Teratogenic Effects

Category C. Animal reproduction studies have not been conducted with any nystatin topical preparation. It also is not known whether these preparations can cause fetal harm when used by a pregnant woman or can affect reproductive capacity. Nystatin topical preparations should be prescribed for a pregnant woman only if the potential benefit to the mother outweighs the potential risk to the fetus.

Nursing Mothers

It is not known whether nystatin is excreted in human milk. Caution should be exercised when nystatin is prescribed for a nursing woman.

Pediatric Use

Safety and effectiveness have been established in the pediatric population from birth to 16 years. (See DOSAGE AND ADMINISTRATION.)

Geriatric Use

Clinical studies with MYCOSTATIN (Nystatin) Cream and MYCOSTATIN (Nystatin) Topical Powder did not include sufficient numbers of subjects aged 65 years and older to determine whether they respond differently than younger subjects. Other reported clinical experience has not identified differences in responses between elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out.

Overdose & Contraindications


No information provided.


Nystatin topical preparations are contraindicated in patients with a history of hypersensitivity to any of their components.

Clinical Pharmacology



Nystatin is not absorbed from intact skin or mucous membrane.


Nystatin is an antibiotic which is both fungistatic and fungicidalin vitro against a wide variety of yeasts and yeast-like fungi, including Candida albicans, C. parapsilosis, C. tropicalis, C. guilliermondi, C. pseudotropicalis, C. krusei, Torulopsis glabrata, Tricophyton rubrum, T. mentagrophytes.

Nystatin acts by binding to sterols in the cell membrane of susceptible species resulting in a change in membrane permeability and the subsequent leakage of intracellular components. On repeated subculturing with increasing levels of nystatin, Candida albicans does not develop resistance to nystatin. Generally, resistance to nystatin does not develop during therapy. However, other species of Candida (C. tropicalis, C. guilliermondi, C. krusei, and C. stellatoides) become quite resistant on treatment with nystatin and simultaneously become cross resistant to amphotericin as well. This resistance is lost when the antibiotic is removed. Nystatin exhibits no appreciable activity against bacteria, protozoa, or viruses.

Medication Guide


Patients using these medications should receive the following information and instructions:

  1. The patient should be instructed to use these medications as directed (including the replacement of missed doses). These medications are not for any disorder other than that for which they are prescribed.
  2. Even if symptomatic relief occurs within the first few days of treatment, the patient should be advised not to interrupt or discontinue therapy until the prescribed course of treatment is completed.
  3. If symptoms of irritation develop, the patient should be advised to notify the physician promptly.
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