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Myrbetriq vs. Ditropan

  • Medical and Pharmacy Editor: John P. Cunha, DO, FACOEP
    John P. Cunha, DO, FACOEP

    John P. Cunha, DO, FACOEP

    John P. Cunha, DO, is a U.S. board-certified Emergency Medicine Physician. Dr. Cunha's educational background includes a BS in Biology from Rutgers, the State University of New Jersey, and a DO from the Kansas City University of Medicine and Biosciences in Kansas City, MO. He completed residency training in Emergency Medicine at Newark Beth Israel Medical Center in Newark, New Jersey.

Are Myrbetriq and Ditropan the Same Thing?

Myrbetriq (mirabegron) and Ditropan (oxybutynin chloride) are used to treat overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency.

Myrbetriq and Ditropan belong to different drug classes. Myrbetriq is a beta-3 adrenergic agonist and Ditropan is an antispasmodic and anticholinergic.

Side effects of Myrbetriq and Ditropan that are similar include dry mouth, diarrhea, constipation, headache, dizziness, blurred vision, stomach pain, or nausea.

Side effects of Myrbetriq that are different from Ditropan include increased blood pressure, inability to fully empty the bladder (urinary retention), sinus pain, sore throat, bloating, memory issues, joint pain, or tired feeling.

Side effects of Ditropan that are different from Myrbetriq include drowsiness, dry eyes, vomiting, upset stomach, unusual taste in mouth, dry/flushed skin, weakness, sleep problems, or runny nose.

Myrbetriq may interact with metoprolol, desipramine, or digoxin.

Ditropan may interact with other bladder or urinary medications, glycopyrrolate, flecainide, mepenzolate, thioridazine, HIV /AIDS medicine, antibiotics, antifungal medications, atropine, benztropine, dimenhydrinate, methscopolamine, scopolamine, bronchodilators, irritable bowel medications, or antidepressants.

What Are Possible Side Effects of Myrbetriq?

Common side effects of Myrbetriq include:

  • drowsiness,
  • dizziness,
  • constipation,
  • nausea,
  • vomiting,
  • loss of appetite,
  • dry mouth, or
  • warmth or redness under the skin.

Tell your doctor if you have any serious side effects of Myrbetriq including:

  • increased blood pressure,
  • the inability to fully empty the bladder (urinary retention),
  • sinus pain,
  • dry mouth,
  • sore throat,
  • diarrhea,
  • constipation,
  • bloating,
  • memory issues,
  • headache,
  • joint pain,
  • dizziness,
  • blurred vision,
  • tired feeling,
  • stomach pain and,
  • nausea.

Tell your doctor if you experience serious side effects of Myrbetriq including

  • fast or pounding heartbeats,
  • pain or burning when you urinate,
  • difficulty urinating,
  • trouble emptying your bladder,
  • or
  • dangerously high blood pressure (severe headache,
  • buzzing in your ears,
  • anxiety,
  • confusion,
  • chest pain,
  • shortness of breath,
  • uneven heartbeats,
  • seizures).

What Are Possible Side Effects of Ditropan?

Common side effects of Ditropan include:

  • dry mouth,
  • dizziness,
  • drowsiness,
  • blurred vision,
  • dry eyes,
  • nausea,
  • vomiting,
  • upset stomach,
  • stomach pain,
  • constipation,
  • diarrhea,
  • headache,
  • unusual taste in mouth,
  • dry/flushed skin,
  • weakness,
  • sleep problems, or
  • runny nose.

Tell your doctor if you experience serious side effects of Ditropan including:

  • decreased sexual activity,
  • difficulty urinating,
  • fast or pounding heartbeat,
  • signs of kidney infection (such as burning/painful/frequent urination, lower back pain, fever),
  • mental/mood changes (such as confusion),
  • swelling of arms/legs/ankles/feet,
  • vision problems (including eye pain),
  • seizures, or
  • stomach or intestinal blockage (such as persistent nausea or vomiting, or prolonged constipation).

What Is Myrbetriq?

Myrbetriq (mirabegron) is a beta-3 adrenergic agonist used to treat overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency.

What Is Ditropan?

Ditropan (oxybutynin chloride) is an antispasmodic and anticholinergic used to treat symptoms of overactive bladder, such as frequent or urgent urination, incontinence (urine leakage), and increased night-time urination. Ditropan is available in generic form.

What Drugs Interact With Myrbetriq?

Myrbetriq may interact with metoprolol, desipramine, or digoxin.

What Drugs Interact With Ditropan?

Some products that may adversely interact with Ditropan include other bladder or urinary medications, glycopyrrolate, flecainide, mepenzolate, thioridazine, HIV /AIDS medicine, antibiotics, antifungal medications, atropine, benztropine, dimenhydrinate, methscopolamine, scopolamine, bronchodilators, irritable bowel medications, or antidepressants. Tell your doctor all medications you are taking. Ditropan should be used only when prescribed by your doctor during pregnancy. Discuss the risks and benefits with your doctor. It is not known whether this drug passes into breast milk. Consult your doctor before breastfeeding.

How Should Myrbetriq Be Taken?

Myrbetriq is available as a 10 mg tablet and a solution (30 mg per ml) for intravenous (IV) or intramuscular (IM) administration. Myrbetriq solution is administered as a single 15- to 60-mg dose once every 6 hours not to exceed 60 or 120 mg a day. The recommended oral dose is one to two Myrbetriq tablets initially followed by one tablet every 4-6 hours, not to exceed 40 mg daily. Myrbetriq should not be used for more than 5 days.

How Should Ditropan Be Taken?

The usual adult dose of Ditropan is one 5-mg tablet 2-3 times a day. The maximum recommended adult dose is one 5-mg tablet four times a day. The usual pediatric dose is one 5-mg tablet two times a day. The maximum recommended pediatric dose is one 5-mg tablet three times a day. Doses may be adjusted by your doctor.

Reviewed on 3/20/2019

References:
Astellas Pharma US, Inc. Myrbetriq Product Information.
https://www.myrbetriq.com
Janssen. Ditropan Product Information.
https://www.janssen.com/canada/sites/www_janssen_com_canada/files/prod_files/live/ditropan_cpm.pdf

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