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Last reviewed on RxList: 5/13/2019
Mysoline Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 5/13/2019

Mysoline (primidone) is an anticonvulsant drug used to control seizures. Side effects of Mysoline include:

Tell your doctor if you have any of serious side effects of Mysoline including:

  • slurred speech,
  • loss of balance or coordination,
  • easy bruising or bleeding, or
  • unusual weakness.

Mysoline is taken orally in tablet form, and the total daily dosage should not exceed 2 g. Mysoline may interact with other drugs. Tell your doctor all medications and supplements you use. The effects of Mysoline (primidone) in human pregnancy and nursing infants are unknown, and these effects are currently under study. The drug is known to be excreted in human milk. Consult your doctor before breastfeeding.

Our Mysoline Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Mysoline Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives, mouth sores, skin rash with blistering and peeling; difficult breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

  • unusual thoughts or behavior;
  • loss of balance or coordination;
  • fever, chills, sore throat;
  • easy bruising or bleeding; or
  • pale skin, unusual tiredness.

Common side effects may include:

  • dizziness, drowsiness, spinning sensation;
  • problems with balance or muscle movement;
  • nausea, vomiting, loss of appetite;
  • feeling tired or irritable;
  • blurred vision;
  • rash; or
  • impotence, sexual problems.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Mysoline (Primidone)


What Is Epilepsy? Symptoms, Causes, and Treatments See Slideshow
Mysoline Professional Information


The most frequently occurring early side effects are ataxia and vertigo. These tend to disappear with continued therapy, or with reduction of initial dosage. Occasionally, the following have been reported: nausea, anorexia, vomiting, fatigue, hyperirritability, emotional disturbances, sexual impotency, diplopia, nystagmus, drowsiness, and morbilliform skin eruptions. Granulocytopenia, agranulocytosis, and red-cell hypoplasia and aplasia, have been reported rarely. These and, occasionally, other persistant or severe side effects may necessitate withdrawal of the drug. Megaloblastic anemia may occur as a rare idiosyncrasy to Mysoline and to other anticonvulsants. The anemia responds to folic acid without necessity of discontinuing medication.

Read the entire FDA prescribing information for Mysoline (Primidone)


If you have had a seizure, it means you have epilepsy. See Answer
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© Mysoline Patient Information is supplied by Cerner Multum, Inc. and Mysoline Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.


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