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Nabi HB

Last reviewed on RxList: 10/29/2009
Nabi HB Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 6/15/2016

Nabi-HB Hepatitis B Immune Globulin (Human) is made from human plasma used to prevent hepatitis B in people receiving a liver transplant, and in babies born to mothers infected with hepatitis B. Nabi-HB is also used to prevent hepatitis B in people who have been exposed to contaminated blood products, or through household or sexual contact with an infected person. Nabi-HB is not a vaccine and will not provide long-term protection from hepatitis B. For long-term protection you must receive a hepatitis B vaccine such as Engerix-B, Recombivax HB, or Twinrix. Nabi-HB is available in generic form. Common side effects of Nabi-HB include:

  • injection site reactions (redness, pain, or tenderness)
  • nausea
  • vomiting
  • upset stomach
  • diarrhea
  • fever
  • chills
  • dizziness
  • headache
  • back or joint pain
  • tremors or shaking, or t
  • iredness

An injection of Nabi-HB 0.06 mL/kg of body weight should be administered intramuscularly as soon as possible after exposure and within 24 hours, if possible. Nabi-HB may interact with other drugs. Tell your doctor all medications and supplements you use and all vaccines you recently received. During pregnancy, Nabi-HB should be used only if prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Our Nabi-HB Hepatitis B Immune Globulin (Human) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Nabi HB Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure);
  • left-sided stomach pain; or
  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

  • upset stomach, diarrhea;
  • tremors or shaking;
  • joint or back pain;
  • fever, chills;
  • headache; or
  • tired feeling.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Nabi HB (Hepatitis B Vaccine Recombinant)

Nabi HB Professional Information


Fifty male and female volunteers received Nabi-HB, Hepatitis B Immune Globulin (Human), intramuscularly in pharmacokinetics trials20. The number of patients with reactions related to the administration of Nabi-HB (hepatitis b vaccine recombinant) included local reactions such as erythema 6 (12%) and ache 2 (4%) at the injection site, as well as systemic reactions such as headache 7 (14%), myal-gia 5 (10%), malaise 3 (6%), nausea 2 (4%), and vomiting 1 (2%). The majority (92%) of reactions were reported as mild. The following adverse events were reported in the phar-macokinetics trials and were considered probably related to Nabi-HB (hepatitis b vaccine recombinant) : elevated alkaline phos-phatase 2 (4%), ecchymosis 1 (2%), joint stiffness 1 (2%), elevated AST 1 (2%), decreased WBC 1 (2%), and elevated creatinine 1 (2%). All adverse events were mild in intensity. There were no serious adverse events.

No anaphylactic reactions with Nabi-HB (hepatitis b vaccine recombinant) have been reported. However, these reactions, although rare, have been reported following the injection of human immune globulins23.

Read the entire FDA prescribing information for Nabi HB (Hepatitis B Vaccine Recombinant)

Related Resources for Nabi HB

© Nabi HB Patient Information is supplied by Cerner Multum, Inc. and Nabi HB Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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