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Nafcillin

Last reviewed on RxList: 8/14/2019
Nafcillin Side Effects Center

Last reviewed on RxList 8/14/2019

Nafcillin (Brand Names: Nallpen, Unipen) is an antibiotic in the penicillin group of drugs used to treat many different types of infections, especially those caused by staphylococcus bacteria ("staph" infections). Nafcillin is available in generic form. Common side effects of Nafcillin include:

Tell your doctor if you have serious side effects of Nafcillin including diarrhea that is watery or bloody; fever, chills, body aches, flu symptoms, sores in your mouth and throat; skin rash, bruising, severe tingling, numbness, pain, muscle weakness; blood in your urine, urinating less than usual or not at all; or pain, swelling, tenderness, or skin changes where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Nafcillin Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives, itching; fever, stomach pain, muscle or joint pain; difficulty breathing; swelling of your face, lips, tongue, or throat.

A delayed allergic reaction to nafcillin can occur as few as 2 days to as many as 4 weeks after you use the medication.

Call your doctor at once if you have:

  • burning, pain, or swelling around the IV needle when the medicine is injected;
  • severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);
  • little or no urination;
  • painful urination, blood or pus in your urine;
  • pain in your side or lower back;
  • pain, swelling, bruising, or skin changes where the medicine was injected;
  • skin rash, itching, joint pain, or not feeling well;
  • fever, chills, swollen glands, sore throat, cough, trouble breathing; or
  • blisters or ulcers in your mouth, red or swollen gums, trouble swallowing.

Common side effects may include:

  • nausea, vomiting, diarrhea;
  • skin rash;
  • black or "hairy" tongue; or
  • tenderness or irritation around the IV needle.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Nafcillin (Nafcillin Sodium)

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Nafcillin Professional Information

SIDE EFFECTS

Body As A Whole

The reported incidence of allergic reactions to penicillin ranges from 0.7 to 10 percent (see WARNINGS). Sensitization is usually the result of treatment, but some individuals have had immediate reactions to penicillin when first treated. In such cases, it is thought that the patients may have had prior exposure to the drug via trace amounts present in milk or vaccines. Two types of allergic reactions to penicillins are noted clinically, immediate and delayed.

Immediate reactions usually occur within 20 minutes of administration and range in severity from urticaria and pruritus to angioedema, laryngospasm, bronchospasm, hypotension, vascular collapse, and death. Such immediate anaphylactic reactions are very rare (see WARNINGS) and usually occur after parenteral therapy but have occurred in patients receiving oral therapy. Another type of immediate reaction, an accelerated reaction, may occur between 20 minutes and 48 hours after administration and may include urticaria, pruritus, and fever.

Although laryngeal edema, laryngospasm, and hypotension occasionally occur, fatality is uncommon. Delayed allergic reactions to penicillin therapy usually occur after 48 hours and sometimes as late as 2 to 4 weeks after initiation of therapy. Manifestations of this type of reaction include serum sickness-like symptoms (i.e., fever, malaise, urticaria, myalgia, arthralgia, abdominal pain) and various skin rashes. Nausea, vomiting, diarrhea, stomatitis, black or hairy tongue, and other symptoms of gastrointestinal irritation may occur, especially during oral penicillin therapy.

Local Reactions

Pain, swelling, inflammation, phlebitis, thrombophlebitis, and occasional skin sloughing at the injection site have occurred with intravenous administration of nafcillin (see DOSAGE AND ADMINISTRATION). Severe tissue necrosis with sloughing secondary to subcutaneous extravasation of nafcillin has been reported.

Nervous System Reactions

Neurotoxic reactions similar to those observed with penicillin G could occur with large intravenous or intraventricular doses of nafcillin especially in patients with concomitant hepatic insufficiency and renal dysfunction (see PRECAUTIONS).

Urogenital Reactions

Renal tubular damage and interstitial nephritis have been associated with the administration of nafcillin. Manifestations of this reaction may include rash, fever, eosinophilia, hematuria, proteinuria, and renal insufficiency.

Hepatic Reactions

Elevation of liver transaminases and/or cholestasis may occur, specifically with administration of high doses of nafcillin.

Gastrointestinal Reactions

Pseudomembranous colitis has been reported with the use of nafcillin. The onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment (see WARNINGS).

Metabolic Reactions

Agranulocytosis, neutropenia, and bone marrow depression have been associated with the use of nafcillin.

Read the entire FDA prescribing information for Nafcillin (Nafcillin Sodium)

Related Resources for Nafcillin

© Nafcillin Patient Information is supplied by Cerner Multum, Inc. and Nafcillin Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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