Reviewed on 8/26/2022

What Is Naftifine and How Does It Work?

Naftifine is a prescription medication used to treat skin infections such as athlete's foot, jock itch, and ringworm infections.

  • Naftifine is available under various brand names: Naftin, Naftin Pump 

What Are Side Effects Associated with Using Naftifine?

Common side effects of Naftifine include:

  • dryness or irritation of treated skin.

Serious side effects of Naftifine include:

  • hives. 
  • difficult breathing. 
  • swelling of the face, lips, tongue, or throat.
  • severe skin irritation after applying this medicine.

Rare side effects of Naftifine include:

  • none

Seek medical care or call 911 at once if you have the following serious side effects:

  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.
  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights.
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheartedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

What Are Dosages of Naftifine?

Adult and pediatric dosage

Topical cream

  • 1%
  • 2%

Topical gel

  • 1%
  • 2%

Tinea corporis

Adult and pediatric dosage

Tinea corporis/tinea cruris: Topical:

  • Cream 1% and 2%, gel 1%: Apply to affected and surrounding area(s) once daily (cream) or twice daily (gel) until clinical resolution, typically 1 to 4 weeks; resolution may be faster with 2% cream

Tinea cruris and pedis

Pediatric dosage

  • Apply to affected and surrounding area(s) once daily (cream and 2% gel) or twice daily (1% gel) until 1 week after the clinical resolution, typically for 2 to 4 weeks total; resolution may be faster with 2% formulations

Dosage Considerations – Should be Given as Follows: 

  • See “Dosages”


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What Other Drugs Interact with Naftifine?

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

  • Naftifine has no noted severe interactions with any other drugs.
  • Naftifine has no noted serious interactions with any other drugs.
  • Naftifine has no noted moderate interactions with any other drugs.
  • Naftifine has no noted minor interactions with any other drugs.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions or concerns.

What Are Warnings and Precautions for Naftifine?


  • Hypersensitivity 

Effects of drug abuse

  • None

Short-Term Effects

  • See “What Are Side Effects Associated with Using Naftifine?”

Long-Term Effects

  • See “What Are Side Effects Associated with Using Naftifine?”


  • Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
  • Naftifine topical gel should not be used on a child younger than 12 years old. Naftifine topical cream is not approved for use by anyone younger than 18 years old.
  • Do not take it by mouth. Topical medicine is for use only on the skin. Rinse with water if this medicine gets in your eyes or mouth.
  • Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication.
  • Call your doctor if the infection you are treating with naftifine topical does not improve within 4 weeks, or if it gets worse.
  • Do not use bandages or dressings that do not allow air circulation over the affected area (occlusive dressings) unless otherwise directed by your doctor. A light cotton-gauze dressing may be used to protect clothing.
  • Do not get this medicine in your eyes, nose, mouth, rectum, or vagina. If contact does occur, rinse with water.
  • Avoid using other medications on the areas you treat with naftifine topical unless your doctor tells you to.
  • Avoid wearing tight-fitting, synthetic clothing that doesn't allow air circulation. Wear loose-fitting clothing made of cotton and other natural fibers until the infection is healed.

Pregnancy and Lactation

  • It is not known whether naftifine topical will harm an unborn baby. Tell your doctor if you are pregnant.
  • Lactation
    • It may not be safe to breastfeed while using this medicine. Ask your doctor about any risks.

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