Naratriptan

Last updated on RxList: 10/29/2020
Naratriptan Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What is Naratriptan and how is it used?

Naratriptan is a serotonin (5-HT 1B/1D) receptor agonist (triptan) used to treat acute migraine with or without aura in adults.

What are the possible side effects of Naratriptan?

Naratriptan may cause serious side effects including:

  • numbness and tingling,
  • nausea,
  • dizziness,
  • drowsiness,
  • feeling unwell (malaise),
  • fatigue, and
  • throat/neck symptoms (pain and pressure)

Dosage for Naratriptan

The recommended dose of naratriptan is 1 mg or 2.5 mg. The dose may be repeated after 4 hours if needed. Do not exceed 5 mg in any 24-hour period.

Naratriptan In Children

Safety and effectiveness of naratriptan in pediatric patients have not been established. Therefore, naratriptan is not recommended for use in patients younger than18 years of age.

What Drugs, Substances, or Supplements Interact with Naratriptan?

Naratriptan may interact with other medicines such as:

  • ergotamine-containing or ergot-type medications (like dihydroergotamine or methysergide),
  • other 5-HT 1 agonists (including triptans),
  • selective serotonin reuptake inhibitors (SSRIs),
  • serotonin norepinephrine reuptake inhibitors (SNRIs),
  • tricyclic antidepressants (TCAs), and
  • monoamine oxidase inhibitors (MAOIs)

Tell your doctor all medications and supplements you use.

Naratriptan During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using Naratriptan; it may harm a fetus. Naratriptan passes into breast milk and may also inhibit lactation. Caution should be exercised when Naratriptan is administered to a nursing mother. Consult your doctor before breastfeeding.

Aditional Information

Our Naratriptan Tablets Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

QUESTION

Who suffers more frequently from migraine headaches? See Answer
Naratriptan Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using naratriptan and call your doctor at once if you have:

  • fast or pounding heartbeats;
  • numbness or tingling and a pale or blue-colored appearance in your fingers or toes;
  • pain or heavy feeling in your legs, hip pain, burning pain in your feet;
  • sudden and severe stomach pain, bloody diarrhea, constipation, fever, weight loss;
  • dangerously high blood pressure--severe headache, blurred vision, pounding in your neck or ears, nosebleed, anxiety, confusion, severe chest pain, shortness of breath, irregular heartbeats, seizure;
  • heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
  • high levels of serotonin in the body--agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting; or
  • signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance.

Common side effects may include:

  • dizziness, drowsiness;
  • feeling weak or tired;
  • numbness or tingling;
  • flushing (warmth, redness, or tingly feeling);
  • nausea; or
  • pain or tightness in your jaw, neck, or throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Naratriptan (Naratriptan Tablets)

SLIDESHOW

16 Surprising Headache Triggers and Tips for Pain Relief See Slideshow
Naratriptan Professional Information

SIDE EFFECTS

The following adverse reactions are discussed in more detail in other sections of the prescribing information:

  • Myocardial ischemia, myocardial infarction, and Prinzmetal's angina [see WARNINGS AND PRECAUTIONS]
  • Arrhythmias [see WARNINGS AND PRECAUTIONS]
  • Chest, throat, neck, and/or jaw pain/tightness/pressure [see WARNINGS AND PRECAUTIONS]
  • Cerebrovascular events [see WARNINGS AND PRECAUTIONS]
  • Other vasospasm reactions [see WARNINGS AND PRECAUTIONS]
  • Medication overuse headache [see WARNINGS AND PRECAUTIONS]
  • Serotonin syndrome [see WARNINGS AND PRECAUTIONS]
  • Increase in blood pressure [see WARNINGS AND PRECAUTIONS]
  • Hypersensitivity reactions [see CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS]

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice.

In a long-term open-label trial where patients were allowed to treat multiple migraine attacks for up to 1 year, 15 patients (3.6%) discontinued treatment due to adverse reactions.

In controlled clinical trials, the most common adverse reactions were paresthesias, dizziness, drowsiness, malaise/fatigue, and throat/neck symptoms, which occurred at a rate of 2% and at least 2 times placebo rate.

Table 1 lists the adverse reactions that occurred in 5 placebo-controlled clinical trials of approximately 1,752 exposures to placebo and naratriptan tablets in adult patients with migraine. Only reactions that occurred at a frequency of 2% or more in groups treated with naratriptan tablets 2.5 mg and that occurred at a frequency greater than the placebo group in the 5 pooled trials are included in Table 1.

Table 1. Adverse Reactions Reported by at Least 2% of Patients Treated With Naratriptan Tablets, USP and at a Frequency Greater Than Placebo

Adverse ReactionNaratriptan Tablets,USP1 mg(n = 627)Naratriptan Tablets, USP 2.5 mg(n = 627)Placebo(n = 498)
Atypical sensation Paresthesias (all types)21421<1
Gastrointestinal Nausea647554
Neurological Dizziness Drowsiness Malaise/fatigue4112722231<11
Pain and pressure sensation Throat/neck symptoms214221

The incidence of adverse reactions in controlled clinical trials was not affected by age or weight of the patients, duration of headache prior to treatment, presence of aura, use of prophylactic medications, or tobacco use. There were insufficient data to assess the impact of race on the incidence of adverse reactions.

Read the entire FDA prescribing information for Naratriptan (Naratriptan Tablets)

© Naratriptan Patient Information is supplied by Cerner Multum, Inc. and Naratriptan Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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