Narcan Nasal Side Effects Center

Last updated on RxList: 10/5/2020
Narcan Nasal Side Effects Center

What Is Narcan Nasal?

Narcan (naloxone hydrochloride) Nasal Spray is an opioid antagonist indicated for the emergency treatment of known or suspected opioid overdose, as manifested by respiratory and/or central nervous system depression. Narcan Nasal Spray is intended for immediate administration as emergency therapy in settings where opioids may be present.

What Are Side Effects of Narcan Nasal?

Common side effects of Narcan Nasal Spray include:

  • increased blood pressure,
  • musculoskeletal pain,
  • headache,
  • nasal dryness,
  • nasal swelling,
  • nasal congestion, and
  • nasal inflammation

Dosage for Narcan Nasal?

The dose of Narcan Nasal Spray is 4 mg of naloxone hydrochloride in 0.1 mL nasal spray.

What Drugs, Substances, or Supplements Interact with Narcan Nasal?

Narcan Nasal Spray may interact with buprenorphine, pentazocine, and other drugs. Tell your doctor all medications and supplements you use.

Narcan Nasal During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant before using Narcan Nasal Spray. Infants born to mothers who use opioids like Narcan Nasal Spray during pregnancy may have withdrawal symptoms. It is unknown how Narcan Nasal Spray may affect a nursing infant. Consult your doctor before breastfeeding. Withdrawal symptoms may occur if you suddenly stop taking Narcan Nasal Spray.

Additional Information

Our Narcan (naloxone hydrochloride) Nasal Spray Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Narcan Nasal Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Because naloxone nasal reverses opioid effects, this medicine may cause sudden withdrawal symptoms such as:

  • nausea, vomiting, diarrhea, stomach pain;
  • fever, sweating, body aches, weakness;
  • tremors or shivering, fast heart rate, pounding heartbeats, increased blood pressure;
  • goose bumps, shivering;
  • runny nose, yawning; or
  • feeling nervous, restless, or irritable.

Sudden withdrawal symptoms in a baby younger than 4 weeks old may be life-threatening if not treated the right way. Symptoms include crying, stiffness, overactive reflexes, and seizures. Call your doctor or get emergency medical help if you are not sure how to properly give this medicine to a baby.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Narcan Nasal (Naloxone Hydrochloride Nasal Spray)

Narcan Nasal Professional Information


The following serious adverse reactions are discussed elsewhere in the labeling:

  • Precipitation of Severe Opioid Withdrawal [see WARNINGS AND PRECAUTIONS]

Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to the rates in the clinical studies of another drug and may not reflect the rates observed in practice.

The following adverse reactions were observed in a NARCAN Nasal Spray clinical study.

In a pharmacokinetic study of 30 healthy adult volunteers exposed to one spray of NARCAN Nasal Spray in one nostril or two sprays of NARCAN Nasal Spray, one in each nostril, the most common adverse reactions were: increased blood pressure, constipation, toothache, muscle spasms, musculoskeletal pain, headache, nasal dryness, nasal edema, nasal congestion, nasal inflammation, rhinalgia, and xeroderma.

The following adverse reactions have been identified primarily during post-approval use of naloxone hydrochloride in the post-operative setting. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure: Hypotension, hypertension, ventricular tachycardia and fibrillation, dyspnea, pulmonary edema, and cardiac arrest. Death, coma, and encephalopathy have been reported as sequelae of these events. Excessive doses of naloxone hydrochloride in post-operative patients have resulted in significant reversal of analgesia, and have caused agitation.

Abrupt reversal of opioid effects in persons who were physically dependent on opioids has precipitated an acute withdrawal syndrome. Signs and symptoms have included: body aches, fever, sweating, runny nose, sneezing, piloerection, yawning, weakness, shivering or trembling, nervousness, restlessness or irritability, diarrhea, nausea or vomiting, abdominal cramps, increased blood pressure, tachycardia. In some patients, there may be aggressive behavior upon abrupt reversal of an opioid overdose. In the neonate, opioid withdrawal signs and symptoms also included convulsions, excessive crying, and hyperactive reflexes.

Read the entire FDA prescribing information for Narcan Nasal (Naloxone Hydrochloride Nasal Spray)

© Narcan Nasal Patient Information is supplied by Cerner Multum, Inc. and Narcan Nasal Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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