Last updated on RxList: 6/7/2021
Nardil Side Effects Center

What Is Nardil?

Nardil (phenelzine) is a monoamine oxidase inhibitor (MAOI), a type of antidepressant, used to treat symptoms of depression that may include feelings of sadness, fear, anxiety, or worry about physical health (hypochondria). Nardil is usually given after other anti-depressants have been tried without successful treatment of symptoms. Nardil is not for treating severe depression or bipolar disorder (manic depression). Nardil is available in generic form.

What Are Side Effects of Nardil?

Common side effects of Nardil include:

  • dizziness,
  • drowsiness,
  • tiredness,
  • weakness,
  • problems sleeping (insomnia),
  • constipation,
  • upset stomach,
  • dry mouth,
  • decreased urination,
  • impotence, or
  • difficulty having an orgasm.

Tell your doctor if you have unlikely but serious side effects of Nardil including:

Dosage for Nardil

The usual starting dose of Nardil is one tablet (15 mg) three times a day. Dosage should be increased to at least 60 mg per day at a fairly rapid pace consistent with patient tolerance.

What Drugs, Substances, or Supplements Interact with Nardil?

There are many other medicines that can cause serious or life-threatening medical problems if you take them together with Nardil. Do not take Nardil before telling your doctor about all other prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor, dentist, or other healthcare provider who treats you.

Nardil During Pregnancy or Breastfeeding

Nardil should be used only when prescribed during pregnancy. It is not known whether this drug passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Nardil (phenelzine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Depression is a(n) __________ . See Answer
Nardil Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

  • sudden and severe headache, neck pain or stiffness;
  • pounding heartbeats or fluttering in your chest;
  • fast or slow heartbeats;
  • chest pain;
  • a light-headed feeling, like you might pass out;
  • sweating (sometimes with fever and sometimes with cold, clammy skin);
  • nausea, vomiting; or
  • dilated pupils (your eyes may be more sensitive to light).

Common side effects may include:

  • dizziness, feeling light-headed;
  • drowsiness, sleep problems;
  • headache;
  • feeling weak or tired;
  • tremors, muscle twitching;
  • dry mouth, stomach discomfort, constipation;
  • swelling, weight gain; or
  • sexual problems.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Nardil (Phenelzine)


Learn to Spot Depression: Symptoms, Warning Signs, Medication See Slideshow
Nardil Professional Information


NARDIL is a potent inhibitor of monoamine oxidase. Because this enzyme is widely distributed throughout the body, diverse pharmacologic effects can be expected to occur. When they occur, such effects tend to be mild or moderate in severity (see below), often subside as treatment continues, and can be minimized by adjusting dosage; rarely is it necessary to institute counteracting measures or to discontinue NARDIL.

Common Side Effects Include

Nervous System - Dizziness, headache, drowsiness, sleep disturbances (including insomnia and hypersomnia), fatigue, weakness, tremors, twitching, myoclonic movements, hyperreflexia.

Gastrointestinal - Constipation, dry mouth, gastrointestinal disturbances, elevated serum transaminases (without accompanying signs and symptoms).

Metabolic - Weight gain.

Cardiovascular - Postural hypotension, edema.

Genitourinary - Sexual disturbances, eg, anorgasmia and ejaculatory disturbances and impotence.

Less Common Mild To Moderate Side Effects (Some Of Which Have Been Reported In A Single Patient Or By A Single Physician) Include

Nervous System - Jitteriness, palilalia, euphoria, nystagmus, paresthesias.

Genitourinary - Urinary retention.

Metabolic - Hypernatremia.

Dermatologic - Pruritus, skin rash, sweating.

Special Senses - Blurred vision, glaucoma.

Although Reported Less Frequently, And Sometimes Only Once, Additional Severe Side Effects Include

Nervous System - Ataxia, shock-like coma, toxic delirium, manic reaction, convulsions, acute anxiety reaction, precipitation of schizophrenia, transient respiratory and cardiovascular depression following ECT.

Gastrointestinal - To date, fatal progressive necrotizing hepatocellular damage has been reported in very few patients. Reversible jaundice.

Hematologic - Leukopenia.

Immunologic - Lupus-like syndrome

Metabolic - Hypermetabolic syndrome (which may include, but is not limited to, hyperpyrexia, tachycardia, tachypnea, muscular rigidity, elevated CK levels, metabolic acidosis, hypoxia, coma and may resemble an overdose).

Respiratory - Edema of the glottis.

General - Fever associated with increased muscle tone.

Withdrawal may be associated with nausea, vomiting, and malaise.

An uncommon withdrawal syndrome following abrupt withdrawal of NARDIL has been infrequently reported. Signs and symptoms of this syndrome generally commence 24 to 72 hours after drug discontinuation and may range from vivid nightmares with agitation to frank psychosis and convulsions. This syndrome generally responds to reinstitution of low-dose NARDIL therapy followed by cautious downward titration and discontinuation.

Read the entire FDA prescribing information for Nardil (Phenelzine)

© Nardil Patient Information is supplied by Cerner Multum, Inc. and Nardil Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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