Navstel Side Effects Center

Last updated on RxList: 8/15/2022
Navstel Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Navstel?

Navstel (balanced salt ophthalmic solution) is a sterile intraocular irrigating solution for use during ophthalmic surgical procedures, involving perfusion of the eye (e.g. vitrectomy and anterior segment reconstruction).

What Are Side Effects of Navstel?

Common side effects of Navstel include:

  • eye discomfort
  • blurred vision
  • dry eye
  • eye swelling
  • eye redness
  • other eye problems, and
  • headache

Navstel may cause serious side effects including:

  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • eye discomfort,
  • eye swelling,
  • redness or itching of the eye,
  • feeling like something is in your eyes,
  • reduced vision,
  • eye pain,
  • abnormally shaped pupils,
  • increased sensitivity to light,
  • seeing halos around lights,
  • red eyes,
  • tearing of the eyes,
  • seeing “floaters” or “cobwebs”,
  • hazy vision,
  • rapid flashes of light in the peripheral vision, and
  • sudden blindness or vision loss

Get medical help right away, if you have any of the symptoms listed above.

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Navstel

Dosing of Navstel is determined by a physician.

What Drugs, Substances, or Supplements Interact with Navstel?

Navstel may interact with other drugs. Tell your doctor all medications and supplements you use.

Navstel During Pregnancy or Breastfeeding

During pregnancy, Navstel should be used only if prescribed. Consult your doctor before breastfeeding.

Additional Information

Our Navstel (balanced salt ophthalmic solution) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

QUESTION

What causes dry eyes? See Answer
Navstel Professional Information

SIDE EFFECTS

Clinical Studies Experience

Increased intraocular pressure was the most frequently reported adverse reaction which occurred in 12% of the 391 patients exposed to NAVSTEL® (balanced salt ophthalmic solution) Solution and 11% of the 431 patients exposed to BSS PLUS® Solution.

The following table presents the incidence of patients with IOP ≥ 25 mmHg. IOP lowering medication was not administered until after the first IOP assessment at hour 6 (anterior segment studies) or Day 1 (posterior segment study).

Table 1: Anterior Segment Studies

Treatment NAVSTEL®
N=223
BSS PLUS®
n=220
IOP ≥ 25 mmHg % %
Hour 6 38 35
Day1 17 15
Day3 6 4
Day7 0.5 0
Posterior Segment Study
Treatment NAVSTEL®
N=168
BSS PLUS®
n=176
IOP ≥ 25 mmHg % %
Day1 7 5
Day7 8 8
Day14 10 4
Day 30 4 4

Table 2 presents the most common adverse reactions reported with NAVSTEL® (balanced salt ophthalmic solution) and BSS PLUS.

Table 2

Treatment NAVSTEL®
N=391
BSS PLUS®
n=431
Coded Adverse Reactions % %
Nervous system disorders
  Headache 3 3
Eye disorders
  Ocular Discomfort 5 3
  Macular Edema 4 4
  Conjunctival Hyperemia 4 3
  Dry Eye 3 5
  Iritis 3 1
  Retinal Hemorrhage 3 1
  Vision Blurred 2 1
  Posterior Capsule Opacification 2 3

In the posterior segment surgical study, cataract was reported in 11% of patients exposed to NAVSTEL® (balanced salt ophthalmic solution) , compared to 7% of patients exposed to BSS PLUS® .

Read the entire FDA prescribing information for Navstel (Balanced Salt Ophthalmic Solution)

SLIDESHOW

Pink Eye (Conjunctivitis) Symptoms, Causes, Treatments See Slideshow

© Navstel Patient Information is supplied by Cerner Multum, Inc. and Navstel Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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