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Nayzilam vs. Keppra

Reviewed on 9/26/2019

Are Nayzilam and Keppra the Same Thing?

Nayzilam (midazolam) Nasal Spray and Keppra (levetiracetam) are used to treat seizures in people with epilepsy.

Nayzilam is specifically used for acute treatment of intermittent, stereotypic episodes of frequent seizure activity (i.e., seizure clusters, acute repetitive seizures) that are distinct from a patient's usual seizure pattern in patients with epilepsy 12 years of age and older.

Nayzilam and Keppra belong to different drug classes. Nayzilam is a benzodiazepine and Keppra is an anti-epileptic drug (AED) (anticonvulsant).

Side effects of Nayzilam and Keppra that are similar include drowsiness.

Side effects of Nayzilam that are different from Keppra include headache, nasal discomfort, throat irritation, and runny nose.

Side effects of Keppra that are different from Nayzilam include weakness, infection, loss of appetite, stuffy nose, tiredness, dizziness, sleepiness, accidental injury, hostility, and nervousness.

Both Nayzilam and Keppra may interact with alcohol.

Nayzilam may also interact with other drugs that can make you sleepy (other benzodiazepines and sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, opioids,), ketoconazole, itraconazole, and clarithromycin.

Keppra may also interact with phenytoin, valproate, oral contraceptives, digoxin, warfarin, and probenecid.

Withdrawal symptoms may occur if you suddenly stop taking Nayzilam.

What Are Possible Side Effects of Nayzilam?

Common side effects of Nayzilam include:

  • drowsiness,
  • headache,
  • nasal discomfort,
  • throat irritation, and
  • runny nose

What Are Possible Side Effects of Keppra?

Common side effects of Keppra include:

Side effects of Keppra in adults include<:/p>

  • drowsiness,
  • weakness,
  • infection,
  • loss of appetite,
  • stuffy nose,
  • tiredness, and
  • dizziness.

Side effects of Keppra in children include

  • sleepiness,
  • accidental injury,
  • hostility, nervousness, and
  • weakness.

What Is Nayzilam?

Nayzilam (midazolam) is a benzodiazepine indicated for the acute treatment of intermittent, stereotypic episodes of frequent seizure activity (i.e., seizure clusters, acute repetitive seizures) that are distinct from a patient's usual seizure pattern in patients with epilepsy 12 years of age and older.

What Is Keppra?

Keppra is indicated as adjunctive therapy in the treatment of partial onset seizures in adults and children 1 month of age and older with epilepsy.

Keppra is indicated as adjunctive therapy in the treatment of myoclonic seizures in adults and adolescents 12 years of age and older with juvenile myoclonic epilepsy.

Keppra is indicated as adjunctive therapy in the treatment of primary generalized tonic-clonic seizures in adults and children 6 years of age and older with idiopathic generalized epilepsy.

SLIDESHOW

What Is Epilepsy? Symptoms, Causes, and Treatments See Slideshow

What Drugs Interact With Nayzilam?

Nayzilam may interact with other drugs that can make you sleepy (other benzodiazepines and sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, opioids, alcohol), ketoconazole, itraconazole, and clarithromycin. Tell your doctor all medications and supplements you use.

What Drugs Interact With Keppra?

Keppra may interact with alcohol.

How Should Nayzilam Be Taken?

The initial dose of Nayzilam is one spray (5 mg dose) administered into one nostril. A second dose of one additional spray (5 mg dose) Nayzilam may be administered into the opposite nostril after 10 minutes if the patient has not responded to the initial dose.

How Should Keppra Be Taken?

Keppra (levetiracetam) is available in pills in the following dosages and colors: 250 mg (blue), 500 mg (yellow), 750 mg (orange), and 1,000 mg (white). Keppra (levetiracetam) is also available as a clear, colorless grape-flavored liquid at a concentration of 100 mg/mL.

Take Keppra exactly as prescribed.

  • Your healthcare provider will tell you how much Keppra to take and when to take it. Keppra is usually taken twice a day. Take Keppra at the same times each day.
  • Your healthcare provider may change your dose. Do not change your dose without talking to your healthcare provider.
  • Take Keppra with or without food.
  • Swallow the tablets whole. Do not chew or crush tablets. Ask your healthcare provider for Keppra oral solution if you cannot swallow tablets.
  • If your healthcare provider has prescribed Keppra oral solution, be sure to ask your pharmacist for a medicine dropper or medicine cup to help you measure the correct amount of Keppra oral solution. Do not use a household teaspoon. Ask your pharmacist for instructions on how to use the measuring device the right way.
  • If you miss a dose of Keppra, take it as soon as you remember. If it is almost time for your next dose, just skip the missed dose. Take the next dose at your regular time. Do not take two doses at the same time.
  • If you take too much Keppra, call your local Poison Control Center or go to the nearest emergency room right away.

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References

FDA. Nayzilam Drug Information.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211321s000lbl.pdf

UCB. Keppra Drug Information.

http://www.keppraxr.com/

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