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Neggram Caplets

Last reviewed on RxList: 6/1/2017
Neggram Caplets Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 6/15/2016

NegGram (nalidixic acid) is an antibiotic used to treat urinary tract infections caused by susceptible gram-negative microorganisms, including the majority of E. Coli, Enterobacter species, Klebsiella species, and Proteus species. The brand name NegGram is discontinued, but generic versions may be available. Common side effects of NegGram (nalidixic acid) include:

  • drowsiness
  • weakness
  • headache
  • dizziness or spinning sensation (vertigo)
  • visual disturbances
  • abdominal or stomach pain
  • nausea
  • vomiting
  • diarrhea
  • rash
  • hives
  • itching, and
  • joint pain or stiffness

The recommended dosage of NegGram for initial therapy in adults is 1 g administered four times daily for one or two weeks (total daily dose, 4 g). NegGram may interact with theophylline, caffeine, anticoagulants, other antibiotics, probenecid, melphalan, antacids, sucralfate, iron, multivitamins containing zinc, didanosine, and cyclosporine. Tell your doctor all medications and supplements you use. During pregnancy, NegGram should be used only if prescribed. This drug passes into breast milk. Breastfeeding while using NegGram is not recommended.

Our NegGram (nalidixic acid) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


How much urine does the average adult pass each day? See Answer
Neggram Caplets Professional Information


Reactions reported after oral administration of NegGram include the following:

CNS effects

Drowsiness, weakness, headache, dizziness and vertigo. Reversible subjective visual disturbances without objective findings have occurred infrequently (generally with each dose during the first few days of treatment). These reactions include overbrightness of lights, change in color perception, difficulty in focusing, decrease in visual acuity, and double vision. They usually disappeared promptly when dosage was reduced or therapy was discontinued. Toxic psychosis or brief convulsions have been reported rarely, usually following excessive doses. In general, the convulsions have occurred in patients with predisposing factors such as epilepsy or cerebral arteriosclerosis. In infants and children receiving therapeutic doses of NegGram, increased intracranial pressure with bulging anterior fontanel, papilledema, and headache has occasionally been observed. A few cases of 6th cranial nerve palsy have been reported. Although the mechanisms of these reactions are unknown, the signs and symptoms usually disappeared rapidly with no sequelae when treatment was discontinued.


Abdominal pain, nausea, vomiting, and diarrhea.


Rash, pruritus, urticaria, angioedema, eosinophilia, arthralgia with joint stiffness and swelling, and anaphylactoid reaction, including anaphylactic shock. Erythema Multiforme and Stevens-Johnson syndrome have been reported with nalidixic acid and other drugs in this class. Rash was the most frequently reported adverse reaction. Photosensitivity reactions consisting of erythema and bullae on exposed skin surfaces usually resolve completely in 2 weeks to 2 months after NegGram is discontinued; however, bullae may continue to appear with successive exposures to sunlight or with mild skin trauma for up to 3 months after discontinuation of drug. (See PRECAUTIONS)


Rarely, cholestasis, paresthesia, metabolic acidosis, thrombocytopenia, leukopenia, or hemolytic anemia, sometimes associated with glucose 6-phosphate dehydrogenase deficiency and peripheral neuropathy.

Read the entire FDA prescribing information for Neggram Caplets (Nalidixic Acid)


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Related Resources for Neggram Caplets

© Neggram Caplets Patient Information is supplied by Cerner Multum, Inc. and Neggram Caplets Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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