Last updated on RxList: 7/12/2021
Neggram Side Effects Center

What Is NegGram?

NegGram (nalidixic acid) Oral Suspension is a quinolone antibiotic used to treat urinary tract infections. NegGram is available in generic form.

What Are Side Effects of NegGram?

Common side effects of NegGram include:

  • drowsiness,
  • weakness,
  • headache,
  • dizziness,
  • spinning sensation (vertigo),
  • abdominal pain,
  • nausea,
  • vomiting,
  • stomach cramps,
  • diarrhea,
  • rash,
  • skin sensitivity to sunlight,
  • itching,
  • hives,
  • skin swelling,
  • reversible visual disturbances (difficulty focusing, double vision, sensitivity to bright lights, changes in color perception, and decreases in visual sharpness), and
  • joint pain and stiffness.

Dosage for NegGram

The recommended dosage of NegGram is 1 gram taken four times a day for one or two weeks, and 2 grams per day thereafter.

What Drugs, Substances, or Supplements Interact with NegGram?

Warfarin, tetracycline, chloramphenicol, nitrofurantoin, probenecid, melphalan, didanosine, and cyclosporine may interact with NegGram. Do not stop taking NegGram unless directed by your doctor. Avoid excess sunlight while taking NegGram. Do not drive, use machinery, or do other activity requiring full alertness while using NegGram.

NegGram During Pregnancy or Breastfeeding

If you are pregnant only take NegGram if the potential benefit outweighs the potential risk to the fetus. Do not take NegGram if you are breastfeeding.

Additional Information

Our NegGram (nalidixic acid, USP) Oral Suspension Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Neggram Professional Information


Reactions reported after oral administration of NegGram include the following.

CNS effects

drowsiness, weakness, headache, dizziness and vertigo. Reversible subjective visual disturbances without objective findings have occurred infrequently (generally with each dose during the first few days of treatment). These reactions include overbrightness of lights, change in color perception, difficulty in focusing, decrease in visual acuity, and double vision. They usually disappeared promptly when dosage was reduced or therapy was discontinued. Toxic psychosis or brief convulsions have been reported rarely, usually following excessive doses. In general, the convulsions have occurred in patients with predisposing factors such as epilepsy or cerebral arteriosclerosis. In infants and children receiving therapeutic doses of NegGram, increased intracranial pressure with bulging anterior fontanel, papilledema, and headache has occasionally been observed. A few cases of 6th cranial nerve palsy have been reported. Although the mechanisms of these reactions are unknown, the signs and symptoms usually disappeared rapidly with no sequelae when treatment was discontinued.


abdominal pain, nausea, vomiting, and diarrhea.


rash, pruritus, urticaria, angioedema, eosinophilia, arthralgia with joint stiffness and swelling, and anaphylactoid reaction, including anaphylactic shock. Erythema Multiforme and Stevens-Johnson syndrome have been reported with nalidixic acid and other drugs in this class. Rash was the most frequently reported adverse reaction. Photosensitivity reactions consisting of erythema and bullae on exposed skin surfaces usually resolve completely in 2 weeks to 2 months after NegGram is discontinued; however, bullae may continue to appear with successive exposures to sunlight or with mild skin trauma for up to 3 months after discontinuation of drug. (See PRECAUTIONS.)


rarely, cholestasis, paresthesia, metabolic acidosis, thrombocytopenia, leukopenia, or hemolytic anemia, sometimes associated with glucose 6-phosphate dehydrogenase deficiency and peripheral neuropathy.

Read the entire FDA prescribing information for Neggram (Nalidixic Acid)


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© Neggram Patient Information is supplied by Cerner Multum, Inc. and Neggram Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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