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Last reviewed on RxList: 3/18/2019
Neo-Synalar Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 3/18/2019

Neo-Synalar [neomycin sulfate 0.5% (0.35% neomycin base), fluocinolone acetonide 0.025%] Cream is a combination of an antibiotic and a corticosteroid indicated for the treatment of corticosteroid-responsive dermatoses with secondary infection. Common side effects of Neo-Synalar include:

  • burning,
  • abnormal hair growth,
  • thinning and breakdown of the skin,
  • itching,
  • acne,
  • secondary infection,
  • irritation,
  • skin discoloration,
  • dry skin,
  • rash around the mouth,
  • stretch marks,
  • “hair bumps,”
  • allergic contact dermatitis and
  • rash.

Neo-Synalar cream is generally applied to the affected area as a thin film dose from two to four times daily depending on the severity of the condition. Neo-Synalar may interact with other drugs. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Neo-Synalar. Corticosteroids such as Neo-Synalar should not be used extensively on pregnant patients, in large amounts, or for prolonged periods of time. It is unknown whether topical Neo-Synalar passes into breast milk. Systemically administered corticosteroids pass into breast milk in quantities unlikely to have a negative effect on the infant. Consult your doctor before breastfeeding.

Our Neo-Synalar [neomycin sulfate 0.5% (0.35% neomycin base), fluocinolone acetonide 0.025%] Cream Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Neo-Synalar Professional Information


The following local adverse reactions are reported infrequently with topical corticosteroids. These reactions are listed in an approximate decreasing order of occurrence:

Maceration of the skin
Acneiform eruptions
Secondary infection
Skin atrophy
Perioral dermatitis
Allergic contact dermatitis

The following adverse reactions have been reported with the topical use of neomycin:


Read the entire FDA prescribing information for Neo-Synalar (Neomycin And Fluocinolone Acetonide Cream)


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© Neo-Synalar Patient Information is supplied by Cerner Multum, Inc. and Neo-Synalar Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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