Neostigmine

Last updated on RxList: 8/4/2021
Neostigmine Side Effects Center

What Is Neostigmine?

Neostigmine methylsulfate injection is an anticholinesterase agent used to treat myasthenia gravis, postoperative distention and urinary retention, and to reverse effects of non-depolarizing neuromuscular blocking agents after surgery.

What Are Side Effects of Neostigmine?

Common side effects of neostigmine methylsulfate include:

Dosage for Neostigmine

Dosage of neostigmine methylsulfate injection depends on the condition being treated.

What Drugs, Substances, or Supplements Interact with Neostigmine?

Neostigmine methylsulfate injection may interact with muscle relaxants, antibiotics, local and some general anesthetics, or antiarrhythmics. Tell your doctor all medications and supplements you use.

Neostigmine During Pregnancy or Breastfeeding

During pregnancy, neostigmine methylsulfate injection should be used only if prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our neostigmine methylsulfate injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Neostigmine Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have muscle weakness as you wake up from surgery.

Common side effects may include:

  • nausea, vomiting; or
  • slow heartbeats.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Neostigmine (Neostigmine Methylsulfate Injection)

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Digestive Disorders: Common Misconceptions See Slideshow
Neostigmine Professional Information

SIDE EFFECTS

Side effects are generally due to an exaggeration of pharmacological effects of which salivation and fasciculation are the most common.Bowel cramps and diarrhea may also occur.

The following additional adverse reactions have been reported following the use of either Neostigmine Bromide or Neostigmine Methylsulfate (neostigmine methylsulfate (neostigmine methylsulfate injection) injection) .

Allergic: Allergic reactions and anaphylaxis.

Neurologic: Dizziness, convulsions, loss of consciousness, drowsiness, headache, dysarthria, miosis and visual changes.

Cardiovascular: Cardiac arrhythmias (including bradycardia, tachycardia, A-V block and nodal rhythm) and nonspecific EKG changes have been reported, as well as cardiac arrest, syncope and hypotension.These have been predominantly noted following the use of the injectable form of Neostigmine Methylsulfate (neostigmine methylsulfate (neostigmine methylsulfate injection) injection) .

Respiratory: Increased oral, pharyngeal and bronchial secretions, dyspnea, respiratory depression, respiratory arrest and bronchospasm.

Dermatologic: Rash and urticaria.

Gastrointestinal: Nausea, emesis, flatulence and increased peristalsis.

Genitourinary: Urinary frequency.

Musculoskeletal: Muscle cramps and spasms, arthralgia.

Miscellaneous: Diaphoresis, flushing and weakness.

Read the entire FDA prescribing information for Neostigmine (Neostigmine Methylsulfate Injection)

© Neostigmine Patient Information is supplied by Cerner Multum, Inc. and Neostigmine Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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